摘要
Abstract
Objective To analyze the Procalcitonin (PCT) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), to optimize the clinical use of antibiotics. Methods 100 patients with AECOPD were randomly divided into experimental group and control group, with 50 cases in each group. The control group were applied with antibiotics according to the patient's symptoms, antibiotic guiding, doctors' experience. While the experimental group were treated with antibiotics according to the detection results of the PCT values on the 1st, 4th, 7th, 10th by delectrochemiluminescence immunoassay. When the serum PCT ≥ 0.25μg, antibiotics were used. The primary outcome was a composite of the use of antibiotic, the average length of stay of patients, the incidence of clinical treatment efficiency and superinfection. Results The use of antibiotics of the experimental group was 70.0%, while that of the control group was 88.0%. The use of antibiotics in the experimental group was significantly lower (χ2=4.882 5, P=0.027 1). Antibiotic use for more than 10 days in the experimental group was significantly lower than that in the control group (χ2=4.373 8, P =0.036 5). The average length of stay for patients in the experimental group was (12.4±2.6) d, significantly shorter than (16.7±3.3) d in the control group (t=7.237 4, P=0.000 0). But the clinical effective rate of the experimental group and the control group was of no statistical significance (χ2=0.795 8, P =0.372 4). Superinfection in the test group was lower than that in the control group (χ2=6.060 6, P =0.013 8). Conclusions Procalcitonin has some guidance in evaluating the use of antibiotics in treating AECOPD. It can significantly shorten the time and usage of antibiotics, and ensure clinical efficacy while reducing superinfection rate.关键词
降钙素原/慢性阻塞性肺疾病急性加重期/优化抗生素使用Key words
Procalcitonin/Acute exacerbation of chronic obstructive pulmonary disease/Optimize antibiotic use分类
医药卫生
