临床医学工程Issue(8)：965-966,969,3.DOI:10.3969/j.issn.1674-4659.2014.08.0965
RBP、HBV DNA和ALB联合检测在监测慢性乙肝患者肝损害的应用意义
Application Significance of Joint Detection of RBP, HBV DNA and ALB in Monitoring the Liver Damage in Patients with Chronic Hepatitis B (CHB)
摘要
Abstract
Objective Through the detection of changes of serum RBP, HBV DNA load and ALB in patients with CHB, we research the related significance and clinical value of the above indicators in monitoring liver damage. Methods We collected serum specimens of 402 cases of CHB patients, and divided into e--CHB and e+-CHB group according to clinical classification to determine the level relations of serum RBP, HBV DNA load and ALB. Results The results showed that the HBV DNA load of e--CHB group (5.04±1.55) was lower than that of e+-CHB group (6.83±1.48) (t=11.73, P<0.01), which was of statistical significance. The levels of serum RBP and ALB of e--CHB group (RBP:14.37±11.07;ALB:30.85±8.9) were lower than those of e+-CHB group (RBP:17.12±8.28;ALB:32.24±4.26) low (t=2.85, P<0.05;t=2.06, P<0.05), which were of statistical significance. The levels of serum RBP and ALB of e--CHB group decreased while HBV DNA load increased. The high and medium copy groups were more statistically significant compared with low copy group (P<0.05). And changes of HBV DNA load of e+-CHB group were not obvious with the changes of serum RBP and ALB. Conclusions According to the clinical classification of patients with CHB, serum HBV DNA load level has different dynamic change with RBP and ALB. For e+-CHB patients, HBV DNA load change has no significant relation with RBP and ALB. For e--CHB patients, HBV DNA load change significantly associates with the degree of liver damage. In addition, the serum RBP can better reflect the damage level of liver function than ALB. In the liver function damage, RBP is superior to ALB.关键词
慢性乙肝(CHB)/e--CHB/e+-CHB/视黄醇结合蛋白(RBP)/HBV DNA/白蛋白Key words
Chronic hepatitis B (CHB)/e--CHB/e+-CHB/Retinol binding protein (RBP)/HBV DNA/Albumin (ALB)分类
医药卫生引用本文复制引用
黄乐升,雷秀霞,龙幼敏,李莉,陈惠玲,徐邦牢..RBP、HBV DNA和ALB联合检测在监测慢性乙肝患者肝损害的应用意义[J].临床医学工程,2014,(8):965-966,969,3.基金项目
广东省科技厅资助项目 （）
