临床医学工程Issue(8)：967-969,3.DOI:10.3969/j.issn.1674-4659.2014.08.0967
柔肝化瘀止痉法防治动脉瘤性蛛网膜下腔出血后迟发性脑血管痉挛的作用及机制
Function and Mechanism of Softening Liver, Resolving Stasis and Relieving Spasm in Preventing and Treating DCVS After aSAH
朱吉祥 1张佛明 1张燕婷 1胡采霞 1夏萍 1薛道金 1石尧 1焦娟 2李贵福 1罗望池 1尤劲松 1陈发军 1马朝晖1
作者信息
- 1. 广东省中医院，广东广州510120
- 2. 湖南中医药高等专科学校附属第一医院，湖南长沙410205
- 折叠
摘要
Abstract
Objective To investigate the efficacy and mechanism of softening liver, resolving stasis and relieving spasm for the prevention and treatment of delayed cerebral vasospasm (DCVS) after aneurysmal subarachnoid hemorrhage (aSAH), and provide clinical basis for the application of traditional Chinese medicine in patients with aSAH. Methods 40 patients with aneurysmal subarachnoid hemorrhage in Guangdong provincial hospital of traditional Chinese medicine were randomly divided into the treatment group (20 cases) and the control group (20 cases). Patients in the treatment group received foundation treatment, nimodipinum and prescription 1 before operation, and foundation treatment, nimodipine and prescription 2 after operation;while patients in the control group received foundation treatment and nimodipine before and after operation. The levels of NO and ET-1 at the third and seventh days after the hemorrhage were detected by Enzyme-linked immunosorbent assay (ELISA). Patient's situation of cerebrovascular spasm was detected by transcranial Doppler (TCD), and patient's Glasgow prognostic score was calculated at discharge and after 3 months. Results There were significant differences between two groups in the incidence of cerebral vasospasm, levels of NO and ET-1 at seventh days after the hemorrhage, artery blood flow velocity of bilateral brain at seventh days after the hemorrhage, and GOS score at the discharge (P<0.05). Conclusions The method of nourishing liver, dispersing blood stasis and preventing cramps has the effect of prevention and treatment of DCVS after aSAH.关键词
动脉瘤性蛛网膜下腔出血/脑血管痉挛/柔肝化瘀止痉法Key words
Aneurysmal subarachnoid hemorrhage/Cerebral vasospasm/Softening liver, resolving stasis and relieving spasm分类
医药卫生引用本文复制引用
朱吉祥,张佛明,张燕婷,胡采霞,夏萍,薛道金,石尧,焦娟,李贵福,罗望池,尤劲松,陈发军,马朝晖..柔肝化瘀止痉法防治动脉瘤性蛛网膜下腔出血后迟发性脑血管痉挛的作用及机制[J].临床医学工程,2014,(8):967-969,3.
