临床医学工程Issue(8)：970-972,3.DOI:10.3969/j.issn.1674-4659.2014.08.0970
阿托伐他汀与水化疗法联用预防PCI术后对比剂肾病的研究
Study of Atorvastatin Statins Combined with Hydration Therapy for the Prevention of Contrast-Induced Nephropathy After Percutaneous Coronary Intervention (PCI)
摘要
Abstract
Objective To explore the clinical value of atorvastatin statins combined with hydration therapy for the prevention of contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI). Methods A total of 120 patients with coronary heart disease treated with selective coronary angiography and interventional treatment were randomly divided into 3 groups. Patients in group A received conventional therapy, including aspirin, nitrates, angiotensin converting enzyme inhibitors, patients in group B received hydration therapy on the basis of conventional therapy, and patients in group C received atorvastatin statins (40 mg) combined with hydration therapy on the basis of conventional therapy. The blood urea nitrogen (BUN), serum creatinine (Scr), urinary microalbumin (mALB), interleukin 18 (IL-18) were detected and the creatinine clearance rate (Ccr) and glomerular filtration rate (GFR) were calculated. Results The number of cases of CIN of the three groups were 7 (17.5%), 4 (10.0%) and 1 (2.5%), respectively, and the incidence of CIN in group B and group C was significantly lower than that of group A (P<0.05), and group C was significantly lower than that of group B (P<0.05). The levels of BUN, Scr, mALB and IL-18 increased significantly after surgery (P<0.05), and the effects were more significant in the group A (P<0.05). The Ccr and GFR decreased significantly after surgery (P <0.05), and the effects were more significant in group A and group B (P <0.05). Conclusions The function of atorvastatin statins combined with hydration therapy is significant in the prevention of contrast-induced nephropathy. It's worthy of application and promotion.关键词
阿托伐他汀/水化疗法/经皮冠状动脉介入治疗/对比剂肾病Key words
Atorvastatin statins/Hydration therapy/Percutaneous coronary intervention (PCI)/Contrast-induced nephropathy (CIN)分类
医药卫生引用本文复制引用
陈友权,蔡万强,余盛龙,郭惠庄,张永霞,陈次滨..阿托伐他汀与水化疗法联用预防PCI术后对比剂肾病的研究[J].临床医学工程,2014,(8):970-972,3.基金项目
广州市卫生局项目（编号：201102A213197）；广州市教育局教育科学规划课题 （）
