临床医学工程Issue(8)：1009-1010,2.DOI:10.3969/j.issn.1674-4659.2014.08.1009
脑苷肌肽联合醒脑静治疗急性颅脑损伤的疗效观察
Curative Effect Observation of Brain Glycosides Carnosine Combined with Xingnaojing Injection for the Treatment of Acute Craniocerebral Injury
张著 1何素娇 1零达尚1
作者信息
- 1. 广东省中山市小榄人民医院神经外科，广东中山528415
- 折叠
摘要
Abstract
Objective To study the clinical curative effect of brain glycosides carnosine combined with Xingnaojing injection for the treatment of acute craniocerebral injury. Methods 104 cases of acute craniocerebral injury patients were randomly divided into two groups. 54 cases of the treatment group received the therapy of brain glycosides carnosine combined with Xingnaojing injection on the basis routine therapy, while 50 cases of control group received routine therapy only. CT examination was used to evaluate the change of cerebral edema volume at 7 d and 14 d of therapy, and Glasgow coma scale (GCS) system and Glasgow outcome scale (GOS) were used to compare patients' outcome between two groups. Results At 7 d of therapy, patients' cerebral edema reached to peak, without statistical difference in the cerebral edema volume before and 7 days after therapy between two groups (P>0.05), but at 14 d of therapy, the cerebral edema volume of treatment group decreased to (2.63±1.02) cm3, significantly less than that of the control group (P<0.05). The conscious rate of the treatment group was 46.3%, significantly higher than that of the control group (P<0.05). At 3 months of follow-up, the excellent and good rate of recovery of treatment group (42.6%) was significantly higher than that of the control group (P<0.05), while the rate of severe disability and death (20.4%) was significantly lower than that of the control group (P<0.05). Conclusions For patients with acute craniocerebral injury, the combination therapy of brain glycosides carnosine and Xingnaojing injection can alleviate neuronal damage and brain edema, improve patients' prognosis and quality of life, and reduce the rate of death and severe disability.关键词
脑苷肌肽/醒脑静/急性颅脑损伤/疗效Key words
Brain glycosides carnosine/Xingnaojing/Acute craniocerebral injury/Curative effect分类
医药卫生引用本文复制引用
张著,何素娇,零达尚..脑苷肌肽联合醒脑静治疗急性颅脑损伤的疗效观察[J].临床医学工程,2014,(8):1009-1010,2.
