摘要
Abstract
Objective To analyze and discuss the feasibility and safety of different doses of atorvastatin in the treatment of elderly patients with coronary artery disease. Methods 68 elderly patients with coronary heart disease in our hospital from October 2011 to October 2013 were selected and randomly divided into two groups, with 34 cases in each group. Patients in the group A were treated with Atorvastatin 40 mg, while patients in group B were treated with Atorvastatin 20 mg. The complication during therapy and the blood fat after therapy were compared between two groups. Results After treatment, the HDL-C level increased, and TG, TC and LDL-C levels decreased in both group, and the differences were statistically significant (P<0.05);The differences of TG, TC and LDL-C after treatment between two groups were statistically significant (P <0.05). Both groups had 1 case (2.94%) of ALT more than 3 times of upper limits of normal (ULN), and both cases returned to normal after drug withdrawal. 6 cases (17.65%) of group A had symptom of angina pectoris at the first one to two months of treatment, while 5 cases (14.71%) of group B had symptom of angina pectoris at the first one to three months of treatment (P>0.05). Conclusions For elderly patients with coronary artery disease, the clinical effect of high dose of atorvastatin is better than that of small dose of atorvastatin, and there is no difference in the safety between two doses. So, we suggest high dose in clinic.关键词
不同剂量/阿托伐他汀/老年冠心病/不良反应/安全性/可行性Key words
Different dose/Atorvastatin/Senile coronary heart disease/Adverse reactions/Safety/Feasibility分类
医药卫生
