临床医学工程Issue(10)：1267-1268,2.DOI:10.3969/j.issn.1674-4659.2014.10.1267
肝再生增强因子在HBV肝硬化患者中的表达及临床研究
Clinical Research and Expression of Augmenter of Liver Regeneration in Liver Cirrhosis Patients with HBV
摘要
Abstract
Objective To study the expression and clinical significance of liver regeneration augmenter in liver cirrhosis patients with HBV. Methods 120 cases of HBV patients with cirrhosis confirmed in our hospital from 2010 to 2013 were selected as observation group, 120 cases taking physical examnation in our hospital were selected as control group. The serum concentration of ALR was detected by ELISA, and the degree of liver cirrhosis of the observation group was tested by FibroScan ultrasound. Results The ALT, Tbil level of the observation group were obviously higher than those of the control group, and the ALB level of the observation group was significantly lower than that of the control group, with significant difference (P<0.01); the concentration of ALR in patients with cirrhosis was significantly higher than that of the control group, with significant difference (P<0.01). Linear correlation analysis indicated that the ALR concentration and liver FibroScan value of the observation group had negative correlation (r2 = -0.197, F = 14.687, P <0.01). Conclusions ALR expression is significantly enhanced in the serum of HBV patients with cirrhosis, having negative correlation with the liver hardness and the occurrence of ascites, which has important clinical significance.关键词
肝再生增强因子/HBV/肝硬化/表达/临床研究Key words
Augmenter of liver regeneration/Hepatitis B virus/Liver cirrhosis/Expression/Clinical research分类
医药卫生引用本文复制引用
吉王琦,李亚维,向贤宏..肝再生增强因子在HBV肝硬化患者中的表达及临床研究[J].临床医学工程,2014,(10):1267-1268,2.基金项目
教育部博士点新教师基金项目“维生素A介导的脂质体-基因复合物调控HSCs基因表达治疗肝硬化的实验研究” （）
