中国医疗设备Issue(11)：5-10,6.DOI:10.3969/j.issn.1674-1633.2014.11.002
阿尔茨海默病不同频段低频振幅静息态功能磁共振成像研究
Resting-State Functional MRI Study on theLow-Frequency Fluctuation within Different Band of Amplitude of Alzheimer’s Disease
摘要
Abstract
Objective To explore the features of brain activity in amplitude of low-frequency lfuctuation (ALFF) within different band of lfuctuation when the Alzheimer’s disease (AD) patients are in resting-state.Methods 20 AD patients and 20 matched healthy controls were examined with Siemens 3.0 T Trio MR scanner. DPARSF (data processing assistant for resting state fMRI) and REST software were used in data processing and statistics, mainly to observe brain activities in frequency bands of Slow-4 and Slow-5. The results were presented by REST software, thus, the anatomical location of brain regions which is of statistical significance was found.Results Compared with healthy controls, AD patients showed significantly decrease of ALFF value in PCC/PCu, bilateral frontal cortex, bilateral inferior parietal cortex. Significantly increased ALFF values were detected in the bilateral parahippocampal gyrus, bilateral fusiform, right frontal-parietal lobe, right cerebellum posterior lobe and basal ganglia. Slow-5 band was more sensitive in detecting abnormalities of spontaneous brain activity in the basal ganglia, while slow-4 band was more sensitive in detecting abnormalities of spontaneous brain activity in the bilateral parahippocampal gyrus and fusiform.Conclusion One or more of AD patients’ brain showed signiifcant differences in the spontaneous neuronal activity compared with healthy controls, and spontaneous neuronal activity in some brain regions is frequency-dependent.关键词
阿尔茨海默病/痴呆/静息态功能磁共振/低频振幅Key words
Alzheimer’s disease/dementia/resting-state functional MRI/amplitude of low-frequency lfuctuation分类
医药卫生引用本文复制引用
肖慧,吴应行,倪萍,付丽媛,李辉,陈自谦..阿尔茨海默病不同频段低频振幅静息态功能磁共振成像研究[J].中国医疗设备,2014,(11):5-10,6.基金项目
福建省社会发展科技重点项目（2012Y0057）“老年性痴呆患者认知功能改变的多模态神经影像研究”。 （）
