中国医疗设备Issue(4)：11-14,4.DOI:10.3969/j.issn.1674-1633.2015.04.003
PET/CT脑成像新药研究发展趋势及基于PET/CT设备的脑成像新药研发
R & D Trends of New Drugs for PET/CT Brain Imaging and R & D of New Drugs for Brain Imaging Based on the PET/CT System
摘要
Abstract
Brain molecular imaging plays an important role in investigations on the function of brain and mechanism of neural diseases. The dopaminergic receptor system is closely related with emotion, love, addiction, incentives, many diseases and disorders. Hereby, taking 18F-fallypride as an example of novel dopamine receptor D2/D3 probes visualizing the Dopamine D2/D3 receptors in striatal and extra-striatal areas, this paper reviews the trends of R&D(Research and Development) and clinical applications of 18F-fallypride, and investigates 18F-fallypride with 15 healthy volunteers’ brain imaging by using the self-innovated AMIC Ray-Scan 64 PET/CT. The result shows a homogeneous and symmetrical distribution of signal in striatal and extra-striatal areas, indicating that the 18F-fallypride, as well as Ray-Scan 64 PET/CT, has demonstrated an excellent performance in dopamine receptor imaging. Additionally, this paper also reviews the progress of clinical uses of 18F-ML-10, a molecular probe to visualize apoptosis. Besides, 10 patients with brain tumorsare investigated by 18F-ML-10-PET/CT imaging pre-and post-radiation with AMIC Ray-Scan 64 PET/CT, in order to evaluate the effect of treatments.关键词
脑成像/分子影像/PET/CT/脑肿瘤/神经Key words
brain imaging/molecular imaging/PET/CT/brain tumors/neural system分类
医药卫生引用本文复制引用
周克迪,王贺宁,李素莹,孟祥溪,孙红芳,任秋实..PET/CT脑成像新药研究发展趋势及基于PET/CT设备的脑成像新药研发[J].中国医疗设备,2015,(4):11-14,4.基金项目
国家重大科学仪器专项（2011YQ030114），国家基础研究计划973项目（2011CB707500），国家自然科学基金（11104058），河北省自然科学基金（A2011201155）。 （）
