摘要
Abstract
Objective To investigate the effects of ACEI(imidapril)on the levels of the CRP and,ventricular remode-ling and heart function in acute myocardial infarction ( AMI) patients without hypertension after thrombolysis .Methods Se-lect 65normotensive patients with AMI and successful thrombolysis , these cases were randomly divided into ACEI treatment group (observation group) with 33 cases, and the conventional treatment group (control group) with 32 cases.The control group received conventional treatment , observation group were given imidapril 5 mg/d with the conventional therapy .Before thrombolysis and after thrombolysis 24 h, 100 d , measured plasma CRP , BNP levels in these patients , measured by echocar-diography with concurrent end-diastolic volume index (EDVI), end-systolic volume index (ESVI), left ventricular ejection fraction (LVEF).Results Compared with those before treatment,24h and 100 d after treatment, CRP and BNP levels were lower in the observation group and the control group ( P <0.05), while the observation group's reduce degree obviously than the control group at 100 d, the difference was statistically significant ( P <0.05).compared with after thrombolysis 24 h, af-ter thrombolytic 100 d, the observation group improvement better than the control group , the differences was significantly (P <0.05).There were statistically significant differences of EDVI , ESVI and LVEF values between the 2 groups ( P <0.05).Conclusion Taking ACEI early in acute myocardial infarction patients could decrease the CRP , BNP levels obvious-ly, and inhibit or reverse ventricular remodeling , improve myocardial ischemia and heart function .关键词
高血压/心肌梗死,急性/心室重构/咪达普利/C反应蛋白/脑钠肽Key words
Hypertension/Myocardial infarction ,acute/Ventricular remodeling/Imidapril/C reactive protein/Natri-uretic peptide
