摘要
Abstract
Objective To study the effects of topiramate on the improvement of brain electrical activity and glucose metabolism in patients with epilepsy .Methods From March 2011 to September 2013 , 90 cases that were diagnosed and trea-ted as epilepsy were randomly divided into observation group and control group with 45 cases in each group , observation group were treated with topiramate and control group treated with valproate , treatment for 6 months.After treatment, two group pa-tients'EEG activity and glucose metabolism were detected .Results After treatment , observation group's number of epilepti-form discharges was (9.56 ±1.03) times/20 min, α, β, δ ,θ wave number was (21.15 ±3.1) times/30s, (21.92 ± 3.95) times/30s, (13.45 ±2.83) times/30s,(10.92 ±2.13) times/30s;in the control group were (14.50 ±2.50) times/20 min, (27.40 ±3.70) times/30s, (16.42 ±2.72) times/30s, (28.50 ±4.64) times/30s, (19.70 ±3.75) times/30s, the differences of 2 groups were statistically significant ( P <0.05).Observed blood glucose levels was (4.32 ±0.52) mmol/L, body mass index was (21.34 ±3.22) kg/m2,lower than the control group [(5.56 ±0.74) mmol/L, (24.78 ± 3.21) kg/m2], serum insulin was (9.94 ±1.42) mU/L in observation group, higher than control group (8.16 ±1.12) mU/L, the difference was statistically significant ( P <0.05),whereas no difference of IR compared with the control group (P >0.05).Conclusion Topiramate can effectively control the electrical activity of brain , but could also lead to abnormal glucose metabolism , including elevated blood glucose levels and decreased blood insulin levels .关键词
癫痫/托吡酯/脑电活动/糖代谢Key words
Epilepsy/Topiramate/Brain electrical activity/Glucose metabolism
