疑难病杂志Issue(6)：597-600,4.DOI:10.3969/j.issn.1671-6450.2014.06.016
局部热疗联合奥沙利铂、多西紫杉醇、5-氟尿嘧啶治疗晚期胃癌的临床随访研究
Clinical follow up study on efficacy of local hyperthermia combined with oxaliplatin, docetaxel, 5-fluorouracil in treatment of advanced gastric cancer
摘要
Abstract
Objective To explore the clinical efficacy of local hyperthermia combined with oxaliplatin (L-OHP), do-cetaxel (DXL) and 5 fluorouracil (5-FU) in the treatment of advanced gastric cancer .Methods Selected from 2009 Septem-ber to 2011 October hospitalized patients of gastric cancer (85 cases), they were randomly divided into observation group (44 cases) and control group (41 cases).Patients in the control group treated by L-OHP+DXL+5 FU with 4 cycles of chemo-therapy, the observation group based on the same chemotherapy , meanwhile synchronous give local thermotherapy , after thera-py, follow-up 24 months, compared the 2 groups'curative effect and 24 months survival rate .Results (1) 2 months after the end of chemotherapy, the observation group total effective rate was 79.5%,clinical benefit rate was 95.5%,KPS score was (77.5 ±5.2)points,these indexes were higher than that of the control group [61.0%,85.4%and (75.2 ±5.5)points],and there was significant difference in KPS score ( P <0.05).(2) During the chemotherapy, drug toxicity type and occurrence of the 2 group were similar;there was no significant difference ( P >0.05).(3) The observation group and the control group's 24 months after chemotherapy survival rate were 43.2%and 34.2%respectively, no significant difference were found (χ2 =0.730, P =0.393), the average survival time was 20.068 (95%CI 19.764-20.373) months, 18.767 (95%CI 18.379-19.155) months, the cumulative survival probabilities were 0.547 ±0.017 and 0.477 ±0.019 respectively, the differences were statistically significant ( t =25.878, P =0.000,χ2 =19.926, P =0.000).Conclusion Combination of local hyper-thermia and L-OHP+DXL+5-FU regimen in treatment of advanced gastric cancer can play a synergistic role in improving life quality with tumor , and prolonging the survival durations .关键词
胃癌,晚期/局部热疗/奥沙利铂/多西紫杉醇/5-氟尿嘧啶/随访研究Key words
Advanced gastric cancer/Local hyperthermia therapy/Oxaliplatin/Docetaxel/5-fluorouracil/Follow-up research引用本文复制引用
卢庆刚,牟安娜,朱礼,张涛..局部热疗联合奥沙利铂、多西紫杉醇、5-氟尿嘧啶治疗晚期胃癌的临床随访研究[J].疑难病杂志,2014,(6):597-600,4.基金项目
辽宁省科技计划项目 （）
