疑难病杂志Issue(6)：625-626,633,3.DOI:10.3969/j.issn.1671-6450.2014.06.025
芪苈强心胶囊对阿霉素所致心力衰竭大鼠氧化损伤的影响
Experimental study of Qiliqiangxin capsule against adriamycin induced oxidative damage in rats with heart failure
摘要
Abstract
Objective To observe Qiliqiangxin capsule on chronic heart failure rat model serum level of superoxide dismutase (SOD), malondialdehyde (MDA).Methods Forty Wistar rats were randomly selected 8 as healthy control group, the other rats by using several intermittent intraperitoneal injection of adriamycin ( ADR) method to establish a rat model of CHF.After the success of modeling , they were randomly divided into model group and Qiliqiangxin capsule group (0.6 g· kg-1· d-1) with 15 rats in each group, health control group and model group were administered with iso-volume of distilled water.After 4 weeks, the rats weight and heart mass were recorded , cardiac index, abdominal aortic blood MDA, SOD levels and serum brain natriuretic peptide levels of BNP were measured and recorded .Results Compared to the control group, cardiac index of the rats in the model group [(3.76 ±0.22) g/kg vs.(2.69 ±0.25) g/kg], BNP [(657 ±59) pg/ml vs.(203 ±31) pg/ml] levels were significantly elevated ( P <0.05), and Qiliqiangxin capsule group were (3.18 ± 0.15) g/kg and (554 ±43) pg/ml, were significantly lower than those in the model group , the difference was statistically significant ( P <0.05).Compared with the healthy control group , levels of serum SOD model group decreased significantly [(113.33 ±10.78) U/ml vs.(197.67 ±12.93) U/ml], MDA levels were significantly higher [(18.72 ±1.79 )nmol/ml vs.(7.73 ±1.53) nmol/ml], the difference was statistically significant ( P <0.05) and Qiliqiangxin capsule group SOD (151.17 ±12.19) U/ml was significantly higher than the model group , the levels of MDA (14.61 ±1.27) nmol/ml was significantly lower than that in the model group , the differences were statistically significant ( P <0.05).Conclusion Qiliqiangxin capsule has a therapeutic effect on chronic heart failure rats .The mechanism may be related to scavenging oxygen free radicals and inhibiting lipid per oxidation .关键词
芪苈强心胶囊/心力衰竭,慢性/阿霉素/大鼠Key words
Qiliqiangxin capsule/Heart failure,chronic/Adriamycin/Rats引用本文复制引用
钱玉红,李争,王敏,范志媛,张淋淋,史俊玲..芪苈强心胶囊对阿霉素所致心力衰竭大鼠氧化损伤的影响[J].疑难病杂志,2014,(6):625-626,633,3.基金项目
2013年度河北省唐山市科技计划项目 （）
