摘要
Abstract
Objective To investigate the relationship between middle-aged cerebral infarction patients with baseline hyperuricemia and within 1 years of the recurrence of cerebral infarction .Methods Collected the clinical data of 253 middle age patients with acute cerebral infarction within 1 weeks , according to baseline levels of uric acid to divide into hyperuricemia group ( n =63) and normal uric acid group ( n =190), a prospective cohort study, compared the clinical data and 1 years proportion of recurrent cerebral infarction of the 2 groups.Results Two groups of patients'gender, history of hypertension , history of diabetes, total cholesterol (TC), triglyceride (TG) was statistically significant differences ( P <0.05), age, coro-nary heart disease, atrial fibrillation, smoking, drinking, family history, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), fasting blood glucose (FPG), fibrinogen (Fib), serum creatinine (SCr), serum albumin (Alb), platelet count (PLT) and proteinuria qualitative test showed no significant differences ( P >0.05).Further correlation analysis suggested that serum uric acid and TC , TG has correlation ( r =0.378, r =0.302, P <0.05).1 years recurrence in 26 cases, the recurrence rate was 10.3%, the hyperuricemia group was 17.5% (11/63), normal uric acid group was 7.9%(15/190), by Kaplan-Meier method (product limit method) analysis suggested that , with significant diffe-rence between 2 groups (Log-rank=4.88, P =0.027).Conclusion Middle-aged cerebral infarction patients'uric acid level is affected by many factors , and the baseline hyperuricemia increases the risk of recurrent cerebral infarction , therefore it should take comprehensive therapy to reduce the recurrence of cerebral infarction .关键词
高尿酸血症/脑梗死/临床特征/复发率Key words
Hyperuricemia/Cerebral infarction/Clinical characteristics/Recurrence rate
