刘剑雄 1张小强 1黄刚 1胡咏梅 1郑庆昆 1陈勇 1刘家勉1
作者信息
摘要
Abstract
Objective To investigate on type 2 diabetes mellitus ( DM) patients with helicobacter pylori ( HP) infec-tion, and to explore the relationship between HP infection and carotid atherosclerosis in patients with type 2 DM.Methods There were 281 patients with type 2 diabetic as DM group , 86 cases of healthy people as healthy control group , observed the HP infection rate , and according to the situation of HP infection in DM patients , they were divided into infection subgroup and non-infection group, compared 2 groups of blood glucose, blood lipid, carotid artery intima media thickness (IMT), inflam-matory cytokines , and explored the relationship between HP infection and carotid atherosclerosis .Results DM patients'HP positive rate was 85.4%(240/281), higher than 47.7%in the healthy control group (41/86), the difference was statisti-cally significant ( P <0.01);all of the DM patients have abnormal metabolism of lipid , HP infected sub group were more significant than in the uninfected group ( P <0.05);the healthy control group , uninfected subgroup and infected subgroup's IMT, CRP, IL-6 and IL-8 increased respectively, IL-10 decreased ( P <0.05).IMT in patients with type 2 diabetes melli-tus was positively correlated with CRP ( r =0.62, P =0.016), IL-6 ( r =0.57, P =0.022) and IL-8 ( r =0.64, P =0.007), and negatively correlated with IL-10 ( r =-0.56, P =0.017).Conclusion It demonstrated that the type 2 dia-betic patients were susceptible to HP , HP persistent infection and carotid atherosclerosis is closely related .关键词
糖尿病,2型/幽门螺杆菌/颈动脉内膜中层厚度/炎性因子Key words
Diabetes,type 2/Helicobacter pylori/Carotid artery intima-media thickness/Inflammatory factor
