疑难病杂志Issue(7)：710-713,4.DOI:10.3969/j.issn.1671-6450.2014.07.016
不同时间给予氟比洛芬酯对结直肠肿瘤切除术患者术后炎性反应的影响
Administration of flurbiprofen axetil at different time in colorectal surgery:effect with postoperative cytokine release
摘要
Abstract
Objective To explore the different time to administrate the flurbiprofen axetil ( FA) injection effects on the expression of plasma inflammatory cytokines in colorectal tumor resection patients .Methods Selected elective colorectal cancer resection patients ( n =40 ) , they were randomly divided into 2 groups , 20 patients in each group .Group A: open skin before operation for 30 min FA 100 mg; group B: after operation skin for 30 min FA 100 mg.Postoperative sufentanil (SF) were performed in patient controlled intravenous analgesia (PCIA).Comparison of 6 h, 24 h of plasma interleukin 2 (IL-2), interleukin 6 (IL-6), interleukin 10 (IL-10), tumor necrosis factor (TNF-α), macrophage-colony stimulating factor ( M-CSF) concentration between the 2 groups before and after the operation .Results Compared with before treatment , the 2 groups'IL 2 levels after 6 h, 24 h were lower, while IL-6 and IL-10 levels were elevated ( P <0.01);compared with group B, after 6 h, 24 h, group A's IL-2 increased, IL-6 reduced ( P <0.05);and compared with group B, after operation for 6h, group A's IL-10 levels was increased ( P <0.05).Patients in the 2 groups at each time point, TNF-αand M-CSF levels showed no statistically significant differences ( P >0.05).Conclusion Intravenous injection of FA 100 mg before operation, and com-bined with patient-controlled intravenous SF analgesia can reduce the expression of inflammatory factor on colorectal tumor pa -tients, while improving the anti-inflammatory cytokines , and promote the recovery of immune function of postoperative patient .关键词
氟比洛芬酯/肿瘤切除术,结直肠/超前镇痛/炎性因子Key words
Flurbiprofen axetil/Tumor resection,colorectal/Preemptive analgesia/Cytokine引用本文复制引用
张瑞芹,林雪,常潘,李迪,刘明远,潘红,王微娜..不同时间给予氟比洛芬酯对结直肠肿瘤切除术患者术后炎性反应的影响[J].疑难病杂志,2014,(7):710-713,4.基金项目
黑龙江省教育厅重点项目 （）
