摘要
Abstract
Objective System evaluation of ivabradine's effective and safty in treatment of stable angina pectoris . Methods From Chinese academic journal full text database (CNKI) (1997-2014.4), Wanfang database (1989-2014. 4), EMBASE (1974-2014.4), PUBMED (1966-2014.4) database retrieval of ivabradine randomized controlled trials on the treatment of stable angina pectoris , the observation group application of ivabradine therapy , the control group application of conventional drugs , with rest and maximum heart rate during exercise , the decreased value of ST segment depression in 1 mm threshold, the value and the movement exercise hypertension duration weighted 5 aspects of the weighted mean difference ( WMD) as indicators of efficacy , the relative risk ( RR) of adverse reactions in 2 groups as the safety index to perform the Meta-analysis.Results A total of 8 randomized controlled clinical trials were included , including 4 582 patients, including 2 439 cases in observation group , 2 143 cases in the control group .The results showed that , the observation group resting heart rate decrease obviously than that in the control group (WMD=4.83, 95% CI 2.39-7.28, P =0.000 1); motion maximum heart rate decrease obviously than that in the control group (WMD=7.22, 95% CI 2.60-11.85, P =0.002);ST segment depression in 1 mm threshold is better than that of the control group (WMD=12.04, 95%CI 2.84-21.25,P=0.01);exercise duration better than the control group (WMD=31.80, 95%CI 25.76-37.84, P <0.01);exercise blood pressure with the highest value of the control group had no significant difference (StdWMD=0.02,95% CI -0.52-0.56, P=0.93);there were no significant difference of adverse reaction between the observation group and the control group (RR=2.43, 95%CI 1.33-4.45, P =0.004).Conclusion Ivabradine in the treatment of stable angina pectoris is well , as well the safety, worthy of clinical application .关键词
伊伐布雷定/心绞痛,稳定型/Meta分析Key words
Ivabradine/Angina pectoris ,stable type/Meta-analysis
