摘要
Abstract
Objective To evaluate tuberculosis infection in T cells spot test ( T-SPOT.TB) combined with fiberoptic bronchoscopy in the diagnosis of children pulmonary tuberculosis .Methods From 2010 March to 2012 Decemberc , 67 cases of children with suspected pulmonary tuberculosis in our hospital were examined by PPD test , ESR, CT, chest T-spot.TB tes-ting, bronchoscopy ( including lavage of Mycobacterium tuberculosis culture , fluorescence quantitative PCR and pathological biopsy) check.Results After checking, pulmonary tuberculosis were diagnosed in 49 cases, chronic or persistent pneumonia in 9 cases, 7 cases of cough variant asthma , 1 cases of bronchial foreign body , 1 cases of lymphoma.Fiberoptic bronchoscopy showed that inflammatory infiltration type in 18 cases (36.7%), 5 cases of caseous necrosis type (10.2%), proliferation of granulation type in 11 cases (22.5%), 15 cases of cicatricial stenosis (30.6%).compared single detection of mycobacteri-um tuberculosis culture and pathological biopsy with clinical diagnosis , poor consistency were found (Kappa =0.09, Kappa=0.29), compared the T-SPOT.TB and FQ-PCR single detection with the clinical diagnosis , general consistency were found (Kappa =0.54, Kappa=0.46).Joint detection:compared fiberoptic bronchoscopy examination (FQ-PCR +Mycobacteri-um tuberculosis culture +biopsy) with the clinical diagnosis, general consistency were found (Kappa =0.55); T-SPOT. TB combined with FQ-PCR detection, good agreement were found (Kappa =0.64), T-SPOT.TB combined with bronchosco-py resulted very high consistency (Kappa =0.85).Conclusion It demonstrated that the T-SPOT.TB bronchoscopy is effec-tive means for diagnosis of pulmonary tuberculosis .关键词
肺结核/结核感染T细胞斑点试验/纤维支气管镜Key words
Pulmonary tuberculosis/Tuberculosis infected T cells spot test/Fiberoptic bronchoscopy
