疑难病杂志Issue(10)：991-994,4.DOI:10.3969/j.issn.1671-6450.2014.10.001
瑞舒伐他汀钙对高血压患者血管活性物质、脉压指数、颈动脉内膜中层厚度的影响及相关性分析
The effects of rosuvastatin on the changes of vasoactive substances, pulse pressure index and intima media thickness in patientsw ith hypertension
摘要
Abstract
Objective To evaluate the effect of rosuvastatin calcium on vasoactive substances , pulse pressure index ( PPI) and carotid artery intima-media thickness ( IMT) in patients with essential hypertension .Methods Eighty hyperten-sive patients were randomly divided into the observation group of 40 cases, with the antihypertensive drug and rosuvastatin cal-cium 10 mg orally 1 time a day, 40 patients in control group only received the antihypertensive drug .Before treatment,after 1 months, 6 months and 12months of treatment , 2 groups of patient’s high sensitivity C reactive protein (hs-CRP), homocys-teine(Hcy),blood pressure,pulse pressure index and intima media thickness were measured and recorded .Results No statis-tical significance differences of before treatment blood pressure , PPI, serum hs-CRP, Hcy and IMT were found between the 2 groups ( P >0.05).Compared with before treatment, after 1 months of treatment, brachial artery systolic blood pressure, PP in the 2 groups were significantly decreased ( P <0.05), and diastolic blood pressure did not change significantly;after 12 months of treatment, the PPI in control group revealed statistical significance differences ( P <0.05), after 1 months of treat-ment, the observation group’s PPI significantly reduced ( P <0.05).Compared with the control group, after 6 months of treatment, the observation group’s PP and systolic blood pressure decreased more significantly ( P <0.05), and treatment for 1, 6, 12 months later, compared with the same period control group , PPI in the observation group had significant differ-ence ( P <0.05).The observation group after treatment ,serum hs -CRP, Hcy concentration and IMT were significantly de-creased ( P <0.05),compared with the control group,the observation group’s hs-CRP had significant differences at the treat-ment of 1,6,12 months ( P <0.05);after treatment for 6,12 months,Hcy in the observation group had statistical significance <br> difference ( P <0 K.05), treatment for 6 months, IMT also had significant difference ( P <0.05).Correlation analysis showed that PPI and serum hs-CRP, the concentration of Hcy and carotid artery IMT were positively correlated ( r =0.606, r = 0.583, r =0.672, P <0.05).Conclusion Rosuvastatin can significantly reduce the plasma vasoactive substances in hypertensive patients , improve IMT and reduce PPI , and thus inhibit the inflammatory reaction , reduce atherosclerotic plaque , improve blood vessel elasticity .关键词
高血压/瑞舒伐他汀/血管活性物质/脉压指数/内膜中层厚度Key words
Hypertension/Rosuvastatin/Vasoactive substance/Pulse pressure index/Intima-media thickness引用本文复制引用
李莉,周元丽,张雪晶,刘丽,王晓琳..瑞舒伐他汀钙对高血压患者血管活性物质、脉压指数、颈动脉内膜中层厚度的影响及相关性分析[J].疑难病杂志,2014,(10):991-994,4.基金项目
国家自然科学基金青年科学基金项目（No．81200211）；山东省优秀中青年科学家科研奖励基金（No．BS2012SW003）；济南市科技明星计划 （）
