疑难病杂志Issue(10)：1051-1053,1057,4.DOI:10.3969/j.issn.1671-6450.2014.10.019
食管鳞癌组织中环氧化酶-2、P-糖蛋白的表达及临床意义
The expression and clinical significance of COX-2 and P-gp in esophageal squamous cell carcinoma
张乐 1梁宗英 1陈健 1辛国华 1侯继申 1张志民 1林建 1张旭1
作者信息
摘要
Abstract
Objective To study the Cyclooxygenase -2(COX-2) and P-glycoprotein (P-gp) expression in esophageal squamous carcinoma tissues and its clinical significance .Methods The immunohistochemical method to detect COX-2 and P-gp in esophageal squamous carcinoma tissues and normal esophageal tissue expression .Results The whole set of esophageal tissue COX-2 expression positive rate was 60.0%(36/60), no expression was found in normal esophageal tissue .COX-2 ex-pression icreased as lesions infiltrating deepens , higher the degree of differentiation , lymph node metastasis and gradually in-crease (χ2 =8.140, P =0.043;χ2 =15.952, P =0.001;χ2 =13.302, P =0.001), the expression of COX-2 was associat-ed with TNM staging,III,IV expression was significantly higher in I ,II period (χ2 =17.778, P =0.001).Full set of esopha-geal tissue P-gp expression positive rate was 45.0%(27/60), normal tissue positive rate was 20.0%(12/60).The expres-sion of P-gp as the tumor infiltration depth deepening ,nodal metastasis and elevated expression (χ2 =10.649, P =0.014;χ2 =6.877, P =0.009) P-gp expression was associated with the TNM staging of esophageal cancer ,III,IV period of expression than I,II period (χ2 =5.455, P =0.020).COX-2 and P-gp in the expression of esophageal squamous carcinoma tissues were positively correlated( r =0.397, P =0.021 ).Conclusion COX-2, P-gp involved in esophageal cancer occurrence , devel-opment and transfer of multiple links .The expression of COX-2 and P-gp were positively correlated , COX-2 can regulate the expression of P-gp through some mechanism , to participate in esophageal multi-resistant adjustment .关键词
食管癌/环氧化酶-2/P-糖蛋白/免疫组化Key words
Esophageal cancer/Cyclooxygenase-2/P-glycoprotein/Immunohistochemistry引用本文复制引用
张乐,梁宗英,陈健,辛国华,侯继申,张志民,林建,张旭..食管鳞癌组织中环氧化酶-2、P-糖蛋白的表达及临床意义[J].疑难病杂志,2014,(10):1051-1053,1057,4.
