疑难病杂志Issue(11)：1126-1129,1133,5.DOI:10.3969/j.issn.1671-6450.2014.11.008
脐血干细胞移植对失代偿期肝硬化肝功能及血流动力学的影响
Effect of liver volume and liver hemodynamics of human umbilical cord blood stem cell transplantation on decompen-sated cirrhosis
摘要
Abstract
Objective To observe the therapeutic effect of umbilical cord blood stem cells transplantation in the treat -ment of decompensated cirrhosis of the liver and the effects on liver hemodynamics .Methods 30 cases of patients with de-compensated liver cirrhosis as treatment group , underwent the proper hepatic artery allogeneic umbilical cord blood stem cell transplantation;chosen the data matched 20 cases of patients with decompensated cirrhosis who did not receive the injection of umbilical cord blood stem cells treatment as the control group .Liver function , coagulation function , hemodynamics of portal vein, B ultrasound contrast agent was compared between the 2 groups of patients .The time of the liver volume and other indi-cators, the clinical symptoms and adverse reaction were observed .Results The success rate of intrahepatic umbilical cord blood stem cell transplantation was 100%in the treatment group , no adverse reaction and complication were occurred. Com-pared with before treatment, after the treatment in the 2 groups, 3, 6 months of glutamate aminotransferase (ALT), aspartate aminotransferase (AST), albumin (Alb) were improved ( P <0.05), and the Alb in the treatment group was better than the control group ( P <0.05 ); and compared with before treatment , in the treatment group , 3, 6 months of total bilirubin (TBil) decreased significantly, control group reduces at 6 months after treatment ( P <0.05);in treatment group, 1, 3, 6 months later , AFP significantly increased , compared with the control group at the same time , the difference was statistically significant( P <0.05).Compared with the treatment group before transplantation ,prothrombin time(PT)after transplantation in 3, 6 months was significantly decreased ( P <0 ?.05), the difference was significant compared with control group ( P <0.05);fibrinogen (Fib) in 3, 6 months after transplantation was significantly increased ( P <0.05), compared with the control group, the difference was not significant ( P >0.05).Thromboplastin time (APTT) and prothrombin time (TT) after transplantation showed a decreasing trend , but with no significant difference before transplantation , the control group had no significant changes ( P >0.05).Compared with before treatment, 2 groups of portal vein diameter (DPV), splenic vein (DSV), portal vein flow velocity (PVX), splenic vein (SVV), portal venous blood flow (QPV), splenic vein blood flow (QSV) did not show statistically significant differences ( P >0.05).After treatment, 2 groups of liver volume were showing increasing trend, but no significant difference were found ( P >0.05).Compared with before treatment, umbilical cord blood stem cell transplantation, the treatment group contrast agent subsided significantly slow down ( P <0.05), compared with the control group, a statistically significant difference were found ( P <0.05).Conclusion The proper hepatic artery umbilical cord blood stem cell transplantation in the treatment of decompensated cirrhosis can improve liver function and blood flow , is a new approach for the treatment of liver diseases .关键词
脐血干细胞/肝硬化/失代偿期/血流动力学Key words
Umbilical cord blood stem cells/Liver cirrhosis/Decompensation/Hemodynamics引用本文复制引用
王可敬,罗晓红,孙厚坦,王方,包建涛..脐血干细胞移植对失代偿期肝硬化肝功能及血流动力学的影响[J].疑难病杂志,2014,(11):1126-1129,1133,5.基金项目
甘肃省自然科学基金项目 （）
