疑难病杂志Issue(12)：1226-1228,1232,4.DOI:10.3969/j.issn.1671-6450.2014.12.005
醛固酮受体拮抗剂螺内酯对围生期心肌病的治疗价值
Efficacy of aldosterone receptor antagonists therapy in patients wi th peripartum cardoi myopathy
摘要
Abstract
Objective To evaluate the effect of aldosterone receptor antagonist spironolactone in the treatment of peri -partum cardiomyopathy (PPCM).Method Collected 72 cases of relatively stable PPCM patients, they were randomly divided into 2 groups, control group and treatment group with 36 cases in each group , they were treated with ACEI/ARB, beta bloc-kers, and trimetazidine, aspirin and other anti-heart failure treatment, the control group maintained the above treatment , treat-ment group based on the above treatment , also used of spironolactone 20 mg, 1 times a day , after 6 months of treatment , the heart rate, blood pressure, left ventricular end diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF), N ter-minal brain precursor , electrolyte and heart function of natriuretic peptide NYHA classification were measured .Results After 6 months of treatment , 2 groups of patients ’ cardiac functional and LVEF have improved , heart rate and NT-proBNP level were decreased , and no death patients were recorded .Compared with the control group , the treatment group ’ s LVEF was in-creased ( P <0.05), heart function, blood pressure, heart rate, NT-proBNP were improved, but the difference was not sta-tistically significant ( P >0.05), and no abnormal increase of blood potassium levels were found , the treatment group’s a-symptomatic survival rate was higher than the control group , but the difference did not reach with statistical significance (85.2%vs.69.1%, Log rank χ2 =1.79, P =0.18).Conclusion Apart from standard anti heart failure drugs , aldoste-rone receptor antagonist give benefit to NYHA class II PPCM whose heart failure are relative steady .Aldosterone receptor an-tagonist enhanced cardiac systolic function , decreased onset of heart failure and do not bring serum potassium abnormal .关键词
心肌病,围生期/醛固酮受体拮抗剂/心力衰竭Key words
Cardiomyopathy/Perinatal period/Aldosterone receptor antagonist/Heart failure引用本文复制引用
黄广勇,张连英,杜静,张雪松,庄芳..醛固酮受体拮抗剂螺内酯对围生期心肌病的治疗价值[J].疑难病杂志,2014,(12):1226-1228,1232,4.基金项目
聊城市科技发展计划项目 （）
