摘要
Abstract
Objective To analyze the clinical characteristics and survival time of patients with dermatomyositis ( DM) combined with malignant tumor .Methods Twenty-four patients with dermatomyositis associated with malignant tumor were enrolled;the clinical data were collected during hospitalization ( including the first symptoms , skin rash, muscular per-formance etc.) and serological indicators (including related antibody, muscle enzyme spectrum, erythrocyte sedimentation rate, and C reactive protein ) were used for data analysis and 3 year follow-up after discharge were performed .Results The 24 cases of dermatomyositis associated with malignant tumor patients were aged between 45-87 years old, male and female ratio was 1∶1.18, including 6 lung cancer cases and 6 nasopharyngeal carcinoma cases (both were 25.0%), 3 cases (12.5%) of breast cancer, 2 cases of ovarian cancer and 2 cases of thymic carcinoma (both were 8.3%), 1 case of renal cell carcinoma , 1 case of gastric cancer , 1 case of cervical cancer , 1 case of intestinal tumor , 1 case of metastasis ( unknown primary tumor ) (both were 4.2%).Among the 24 patients, 13 cases were malignant erythema (54.2%), loss of body mass in 10 cases (41.7%);laboratory examination of anti-nuclear antigem(ANA) positive in 22 cases (91.7%), Jo-1 antibodies was nega-tive in all of these cases.During the follow-up period, 16 cases were dead (66.7%), 8 cases (33.3%) were still alive.The main causes of death include dermatomyositis complications , tumor metastasis related multiple organ failure , pulmonary infec-tion related severe respiratory failure , fulminant hepatitis;all patients were followed up for 3 years, 1 year’s survival rate was 50.0%, 3 year’s survival rate was 33.3%.Conclusion Lung cancer and nasopharyngeal carcinoma were the most common malignant tumors in dermatomyositis patients , followed by breast cancer , ovarian cancer , breast cancer , its revealed high fa-tality rate.Malignant erythema , loss of body weight in patients with dermatomyositis , especially for elderly patients are needed to cautious with potential tumor .关键词
皮肌炎/恶性肿瘤/生存分析Key words
Dermatomyositis/Malignant tumor/Survival analysis
