摘要
Abstract
Objective To investigate the effects of glutamine and lactose free formula feeding on premature infants with necrotizing enterocolitis nutritional status , immune function and gastrointestinal hormone .Methods Sixty premature in-fant with necrotizing enterocolitis were enrolled in the study , they were randomly divided into observation group and control group with 30 cases in each group , the observation group received glutamine and lactose free formula feeding , the control group were received glutamine and breastfeeding , children nutrition status , immune function , gastrointestinal hormone were compared between the 2 groups..Results (1) nutritional status:4 weeks after treatment, albumin, preprotein content in the observation group were significantly higher than those of control group [(112.31 ±15.23) g/L vs.(103.19 ±13.75) g/L, (41.48 ±5.61)g/L vs.(32.58 ±4.46) g/L, P <0.05].(2)Immune function:2 weeks after treatment, CD4+T cells ratio and IgA, IgG, IgM in the observation group were significantly higher than those of control group [(38.11 ±3.91)% vs. (32.52 ±4.84)%, (13.14 ±1.45) g/L vs.(10.12 ±0.73) g/L,(2.86 ±0.33) g/L vs.(1.77 ±0.21) g/L,(1.43 ± 0.19) g/L vs.(1.02 ±0.13) g/L, P <0.05];CD8+T cells ratio was significantly lower than that control group [(21.95 ± 3.13)%vs.(27.51 ±3.76)%, P <0.05].(3) Guthormone levels: gastrin and motilin content in the observation group were significantly higher than those of control group [(292.45 ±35.82) pg/ml vs.(231.38 ±29.14) pg/ml,(121.85 ± 16.34) pg/ml vs.(90.45 ±11.34) pg/ml, P <0.05].Conclusion Glutamine and lactose free formula feeding is helpful to improve the nutritional status , immune function , improve the gastrointestinal tract hormone content , and improve therapeu-tic effect.关键词
小肠结肠炎,坏死性/谷氨酰胺/无乳糖配方奶/营养状况/免疫功能/胃肠激素Key words
Enterocolitis necrotizing/Glutamine/Lactose free formula milk/Nutritional status/Immune function/Gastrointestinal hormone
