疑难病杂志Issue(1)：45-48,4.DOI:10.3969/j.issn.1671-6450.2015.01.014
阿瑞匹坦辅助预防乳腺癌 FAC 方案化疗致恶心呕吐的临床观察
Clinical observation of aprepitant on prevention of nausea and vomiting caused by FAC chemotherapy regimen for breast cancer
丁荣楣 1王平 1田奕 1马丽君 1郭宏1
作者信息
- 1. 110022 沈阳，中国医科大学附属盛京医院第二肿瘤病房
- 折叠
摘要
Abstract
Objective To investigate the effect of aprepitant combined granisetron hydrochloride injection and dexam -ethasone in the prevention of nausea , vomiting induced by FAC regimen chemotherapy of breast cancer .Methods From 2014 January to 2014 June, collected 76 cases of breast cancer patients who were received chemotherapy of FAC regimen in Shengjing Hospital Affiliated to China Medical University , in accordance with the order of admission , they were randomly di-vided into observation group ( aprepitant +granisetron hydrochloride injection +dexamethasone ) and control group ( granise-tron hydrochloride injection +dexamethasone), each group of 38 cases, compared the 2 groups'clinical efficacy of prevention of nausea , vomiting induced by chemotherapy , adverse reactions and the quality of life .Results The observation group nau-sea control rate was 84.2%,which was better than the control group of 65.7%(χ2 =4.324, P <0.05);observation group's acute vomiting efficiency was 81.6%, which was better than the control group of 63.2%(χ2 =4.213, P <0.05);the effec-tive rate of delayed vomiting in the observation group was 79.0%, which was better than the control group of 60.6% (χ2 =3.172, P <0.05).Adverse reactions revealed no significant differences between the 2 groups ( P >0.05);evaluation of the quality of life , the observation group was significantly higher than that in the control group , there was significant difference be-tween the 2 groups ( P <0.05).Conclusion Aprepitant combined granisetron hydrochloride injection and dexamethasone can effectively prevent nausea and vomiting caused by FAC chemotherapy in breast cancer patients with mild adverse reac -tions, it can improve the quality of life of patients and worthy of promotion .关键词
阿瑞匹坦/乳腺癌/FAC方案/化疗/止吐剂Key words
Aprepitant/Breast cancer/FAC regimen/Chemotherapy/Antiemetic agent引用本文复制引用
丁荣楣,王平,田奕,马丽君,郭宏..阿瑞匹坦辅助预防乳腺癌 FAC 方案化疗致恶心呕吐的临床观察[J].疑难病杂志,2015,(1):45-48,4.
