Abstract
Objective To explore the effect of paclitaxel plus platinum regimen in the treatment of advanced cervical cancer patients and effect on CYFRA 21-1, and SCC-Ag.Methods Advanced cervical cancer of 104 cases were randomly di-vided into observation group and control group with 52 cases in each group , the observation group used paclitaxel plus platinum regimen for the treatment , control group used irinotecan plus platinum regimen .Therapeutic effect , the adverse reaction and quality of life, and the serum tumor markers CYFRA21-1, SCC-Ag changes of 2 groups were observed and compared .Results The observation group's effective rate was 67.3%(35/52), which was higher than 44.2% in the control group (23/52) (χ2 =10.815, P <0.05).The 2 groups after treatment's CYFRA21-1, SCC-Ag were lower than those before therapy (2.12 ± 1.03) vs.(4.56 ±2.07) and (1.67 ±1.04) vs.(3.85 ±1.17) ( P <0.05),and the observation group was better than in the control group( t =7.409、9.439, P <0.05).After treatment, 2 groups's physical function, emotional function, social function, fatigue, loss of appetite, pain was improved (observation group:t =3.759,3.964,3.738,3.316,3.670,3.057;control group:t =3.251,2.341,2.465,1.906,2.590,2.317, P <0.05),and except somatic function, the rest of observa-tion group was better than the control group ( t =1.661,1.928,1.764,1.838,1.554, P <0.05),gastrointestinal reactions, bone marrow suppression , muscles and joints the pain , the decrease of white blood cells , platelets decreased in the observation group was significantly lower than that of the control group (χ2 =3.898,2.797,6.522,4.300,2.659, P <0.05), difficulty in breathing , hair loss , liver and kidney function damage incidence revealed no statistical significance difference between the 2 groups (χ2 =0.210,0.070,0.153, P >0.05).Conclusion Paclitaxel combined with platinum chemotherapy in the treat-ment of advanced cervix carcinoma showed exact and high effective rate , fewer adverse reactions , it can prolong the survival time of patients , improve the quality of life of patients , it is worthy of clinical application .关键词
紫杉醇/宫颈癌/卡铂/CYFRA21-1/SCC-AgKey words
Paclitaxel/Cervical cancer/Carboplatin/CYFRA21-1/SCC-Ag
