Abstract
Objective To investigate the effect of N-acetylcysteine ( NAC) as adjuvant treatment on idiopathic pul-monary fibrosis ( IPF) . Methods Applying randomized control method, 42 cases of patients with IPF were divided into obser-vation group and control group according toadmission sequence with 21 cases in each group, the observation group based on the conventional treatment of oral glucocorticoid, patients were used of NAC, the control group were received glucocorticoid oral conventional treatment. The rest basic treatment was the same in the two groups, treated for 6 months. The therapeutic effect of the 2 groups after treatment was evaluated,the pulmonary function[ ( vital capacity,VC) , diffusion capacity for carbon mon-oxide ( DLco) ] , arterial blood gas analysis [ pH value, oxygen partial pressure ( PaO2 ) , oxygen saturation ( SaO2 ) , partial pressure of carbon dioxide ( PaCO2 ) ] index and adverse reaction were observed before and ofter. Results After treatment, in observation group, the total clinical effective rate was 80. 95%,which was higher than that of the control group 52. 38%(χ2 =3.857,P <0.05).Compared with before treatment, the 2 groups after treatment’s VC, DLco decreased, the difference in control group was significant( t =2. 151, t =2. 093, P <0. 05),but no significance was found in observation group( t =0. 419, t =0. 376, P >0. 05). After treatment decrease of VC,DLco in observation group was less than those of control group, there were significant difference (t = -2. 147, t = -2. 083, P <0. 05). Compared with before treatment, pH, PaCO2 has no significant difference( t =0. 861/1. 724, t = -1. 624/ -1. 983, P >0. 05), PaO2,SaO2 were decreased, and the differences in control group were statistically significant ( t =2. 375, t =2. 459, P <0. 05);no significant difference was found in observation group ( t =0.507, t =0.381, P >0.05),after treatment the decrease of PaO2, SaO2 in observation group was less than observation group ( t = -2. 117, t = -3. 426, P <0. 05). No serious adverse reaction was found in the 2 groups. Conclusion For patients with IPF, the conventional corticosteroid therapy added with NAC can effectively improve the symptoms of IPF, and slow down the decrease of pulmonary function, PaO2 , SaO2 .关键词
特发性肺纤维化/N-乙酰半胱氨酸/治疗Key words
Pulmonary fibrosis ,idiopathic/N-acetylcysteine/Treatment
