疑难病杂志Issue(2)：191-195,197,6.DOI:10.3969/j.issn.1671-6450.2015.02.025
阿替普酶与尿激酶静脉溶栓治疗急性心肌梗死疗效与安全性的Meta分析
Efficacy and safety of intravenous thrombolytic therapy with alteplase and urokinase for the treatment of acute myo-cardial infarction:A Meta-analysis
摘要
Abstract
Objective To systemic review the efficacy and safety of alteplase and urokinase thrombolytic therapy in a-cute myocardial infarction. Methods Searched on CBMdisc ( 1978 -2014 September ) , China journal full text database (1994-2014 September), VIP database (1999-2014 September), Wanfang database (1990-2014 September), PubMed (1990-2014 September), Cochrane Library (2014 ninth period). Included alteplase (experimental group) and urokinase ( control group) randomized controlled trial of intravenous thrombolytic therapy in the treatment of acute myocardial infarction (RCTs), scale for assessment formulated by modified Jadad method the quality of the included studies, using RevMan5. 2 Meta analysis. Results A total of 581 literatures were retrieved. According to inclusion and exclusion criteria, finally 17 arti-cles were included for Meta-analysis. The Meta-analysis results: experimental group after thrombolysis ' recanalization rate higher than that of the control group (RR=1. 33, 95%CI 1. 18-1. 48, P <0. 01), bleeding rate lower than that of the con-trol group, (RR = 0. 42, 95%CI 0. 30-0. 58, P <0. 01), arrhythmia incidence was lower than that of the control group (RR = 0. 76, 95%CI 0. 58-0. 98, P =0. 04), re-infarction rate lower than that of the control group (RR = 0. 49, 95%CI 0. 32-0. 75, P =0. 000 9), the mortality rate is lower than the control group (RR = 0. 46, 95%CI 0. 29-0. 71, P =0. 000 5). Conclusion Alteplase intravenous thrombolytic therapy for acute myocardial infarction curative effect is better than that of urokinase.关键词
阿替普酶/尿激酶/溶栓/心肌梗死,急性/疗效/安全性/Meta分析Key words
Alteplase/Urokinase/Thrombolysis/Myocardial infarction,acute/Efficacy/Safety/Meta analysis引用本文复制引用
刘浙波,夏豪,童随阳,王欣,李磊,杨洋,李晶..阿替普酶与尿激酶静脉溶栓治疗急性心肌梗死疗效与安全性的Meta分析[J].疑难病杂志,2015,(2):191-195,197,6.基金项目
国家自然科学基金(No.81270184) （No.81270184）
