疑难病杂志Issue(4)：349-352,4.DOI:10.3969/j.issn.1671-6450.2015.04.006
高三酰甘油性腰围表型与空腹血糖受损对2型糖尿病发病的影响及二者相关性研究
Effect of hypertriglyceridemia waist circumference phenotype and impaired fasting glucose on the incidence of diabe-tes and their corelation
摘要
Abstract
Objective To investigate the hypertriglyceridemia waist circumference phenotype( HTGW) and impaired fasting glucose ( IFG) ’ s independent effects on the pathogenesis of diabetes and correlation.Methods The clinical data of 235 healthy people were recorded and analyzed, using Cox regression model to analyze the relationship of HTGW, IFG, high waist circumference, hypertriglyceridemia ( TG) with the prevalence of diabetes mellitus, and by Cox proportional regression model to stratify the interaction between IFG and HTGW.Results In HTGW( +) and in HTGW( -) objects, compared with IGF(-) objects, IGF(+) objects had higher age, waist circumference, body mass index ( BMI) , systolic blood pres-sure, diastolic blood pressure, total cholesterol (TC), TG, fasting plasma glucose (FPG), low density lipoprotein cholesterol (LDL-C), family history of diabetes and lower high density lipoprotein cholesterol (HDL-C) ( P <0.05); after 5 years of follow-up, new onset diabetes incidence was 4.36%(90/2 066);baseline IFG(+) objects had the highest incidence during follow-up (6.06%, 58/957), HTGW( +) objects had the second incidence of diabetes (3.18%, 10/314); multivariate Cox proportional hazard regression analysis showed that diabetes risk (HR1) and 95%CI values of HTGW( +), IFG( +), high waist circumference and high TG objects were 2.25 (1.49-3.42), 3.44 (2.27-5.22), 1.54 (1.02-1.54) and 1.81 (1.19-2.74), there were statistically significant difference ( P <0.05).After adjustment of each variable, multi fac-tor Cox regression analysis showed that HTGW, IFG and high TG were still correlated with diabetes,HR2 and 95%CI were 2.05 (1.35-3.10), 3.37 (2.23-5.11) and 1.78 (1.17-2.69),with significant difference( P <0.05).But the correlation between high waist circumference and diabetes were disappeared ( P >0 !.05).Cox layered analysis results show that, com-pared with the HTGW(-) and IFG(-) objects, diabetes HR values and the 95%CI in HTGW( +) IFG( +) object was 3.07 (2.03-4.65), after adjustment of each variable, diabetes HR values and the 95%CI of HTGW(+) and IFG(+) ob-ject was 12.33 (8.14-18.68).Conclusion HTGW had independence in the role of predicting diabetes, HTGW and IFG had adding interaction to diabetes.关键词
高三酰甘油性腰围/空腹血糖受损/糖尿病/影响因素/队列研究Key words
Hypertriglyceridemia waist circumference/Impaired fasting glucose/Diabetes mellitus/Influencing fac-tors/Cohort study引用本文复制引用
郭毅飞,李敏,王娜娜,李雪锋..高三酰甘油性腰围表型与空腹血糖受损对2型糖尿病发病的影响及二者相关性研究[J].疑难病杂志,2015,(4):349-352,4.基金项目
湖北省教育厅科学技术研究计划重点项目 （）
