疑难病杂志Issue(5)：445-448,4.DOI:10.3969/j.issn.1671-6450.2015.05.002
大剂量阿托伐他汀对急性心肌梗死患者行PCI术再灌注后ET、NO、slCAM－1及hs－CRP的影响
Effect of high dose atorvastatin on endothelial function in patients with acute myocardial infarction after percutaneous coronary intervention
摘要
Abstract
Objective To observe the effects of high dose atorvastatin on enodthelin-1 ( ET-1) , nitric oxide ( NO) , soluble intercellular adhesion molecule 1 (slCAM-1) and high sensitive C reactive protein (hs-CRP), blood lipid in acute myocardial infarction ( AMI ) patients with percutnaeous coronary intervention ( PCI ) .Methods From September 2012 to September 2014, 113 patients with AMI after PCI were randomly divided into control group (58 cases) and treatment group (55 cases) , 2 groups were treated with routine anticoagulation, antiplatelet, reverse ventricular remodeling drugs, control group based on the conventional therapy added atorvastatin 20 mg orally, the patients in the treatment group were treated with atorvastatin 40 mg orally on the basis of conventional therapy.2 groups of patients at the immediate and after 1, 30 d admis-sion, peripheral blood NO, ET-1, slCAM-1, hs-CRP level and blood lipid level were determined.Observed the effect of dif-ferent doses of atorvastatin on inflammatory markers, endothelial function and blood lipid.Results Compared with before treatment, after 30 d’ s treatment, ET-1, slCAM-1, hs-CRP and lipid levels were decreased in both of the 2 groups ( P <0.05), level of NO were elevated.And at 30 d’s treatment, these indices in the treatment group were more significant than the control group ( P <0.05).No statistically significant differences of adverse reactions were found in the 2 groups ( P >0.05).Conclusion Atorvastatin can decrease the inflammatory reaction of reperfusion after PCI in AMI patients, improve endothelial function, high dose of atorvastatin has more obvious effect than the conventional dose and no obvious adverse reac-tion were found.关键词
心肌梗死,急性/冠状动脉介入/内皮功能/阿托伐他汀Key words
Myocardial infarction,acute/Percutaneous coronary intervention/Endothelial function/Atorvastatin引用本文复制引用
解金红,陈玉善,罗明华,王贺,邱承杰,董文杰..大剂量阿托伐他汀对急性心肌梗死患者行PCI术再灌注后ET、NO、slCAM－1及hs－CRP的影响[J].疑难病杂志,2015,(5):445-448,4.基金项目
河南省教育厅科技重点项目（No．14A320051）；河南省高校科技创新团队（No．13IRTSTHN012）；郑州市科技创新团队项目 （）
