摘要
Abstract
Objective To investigate the changes of serum myeloperoxidase ( MPO) level and its clinical significance in patients with coronary heart disease ( CHD) pre and post percutaneous coronary intervention ( PCI) .Methods Eighty ca-ses of successful PCI patients were enrolled as CHD group, among them, 50 cases of stable angina pectoris were enrolled as SAP subgroup, 30 patients with unstable angina pectoris were enrolled as UAP subgroup, and according to coronary Gensini score, they were divided into severe lesions subgroup ( n =32) and non-severe leisions subgroups ( n =48);selected non-CHD volunteers 20 cases as healthy control group.The changes of serum MPO levels before and 1 h and 24h post PCI were observed,the relationship between these clinical indexes were analyzed .Resu lts The SAP subgroup and UAP subgroup ’ s MPO and CRP levels were higher than those in healthy control group ( P <0.05).Compared with pre PCI, 1 h post PCI, MPO level were increased ( P <0.05) , after 24h, it was felled.Severe lesions subgroups’ preoperative MPO and CRP levels were higher than those in non-severe lesion group ( P <0.05).After PCI treatment, the severe lesion group after PCI 1h ’s level were still significantly higher than the non-severe lesion group ( P <0.05).After 24 h and △1 (after 1 h to before PCI ) ,△3 ( postoperative 24 h to 1 h after operation) , ROC analysis revealed that the levels of MPO helped to predict MACE (AUC were 0.823, 0.769 and 08.45 respectively, P <0.05).△1 (1 h after PCI to before PCI) and MACE exist positive correlation ( r =0.372, P <0.05),△1 and the Gensini score exists positive correlation ( r =0.392, P <0.05).△3 (24 h after PCI to 1 h after PCI) and MACE exist negative correlation ( r =-0.329, P <0.05), there is a negative correla-tion with Gensini score ( r =-0.435, P <0.05).Logistic regression analysis indicated that the Gensini score (OR=1.03, 95%CI 0.92-1.32, P <0.05) and△3 (OR=1.12, 95%CI 0.94-1.45, P <0.05) were independent risk factors of MACE.Conclusion After PCI, serum MPO showed fluctuation in CHD patients.This change correlated with the severity of coronary artery stenosis and clinical prognosis.关键词
冠心病/经皮冠状动脉介入术/血清髓过氧化物酶Key words
Coronary heart disease/Percutaneous coronary intervention/Serum myeloperoxidase
