Abstract
Objective To investigate the effect of the surgical treatment for gliomas and the risk factors for 1 years after surgery prognosis. Methods From September 2012 to September 2014, 80 cases of brain glioma patients were enrolled, according to the random number table method, they were divided into study group and control group, each group with 40 ca-ses, the study group underwent total resection and subtotal resection, and the control group received routine craniotomy, 1 d before surgery, 3 months, 6 months after surgery,the cognitive function ( MMSE score) and activities of daily living ( ADL) were compared between the two groups, and detected cerebrospinal fluid ( CSF) and arginine vasopressin ( AVP) and oxytocin ( OT) , beta endorphin (β-EP) , tumor necrosis factor alpha ( TNF-α) levels. The patients were followed up for 1 year, and the relationship between gender, age, tumor grade, tumor size, and prognosis was analyzed. Results After 1 year’ s MMSE score in study group was significantly higher than that of control group, ADL score was significantly lower than that of control group ( t =9. 372, t =5. 100, P <0. 05);two groups of patients’ postoperative AVP, OT, beta EP, TNF-αlevel were sig-nificantly decreased ( P <0. 05). The postoperative 3 months, 6 months’ AVP, OT, β-EP in study group were significant higher than the same time’s control group ( P <0. 05), and TNF-α level’s difference had no statistical significance ( P >0. 05). After operation, study group had hemiplegia in 5 cases, 2 cases of aphasia, complication rate was 17. 5% (7/40);control group had hemiplegia in 5 cases, 1 cases of aphasia, 3 cases of infection, complication rate was 22. 5% (9/40), two groups of patients’ postoperative complication rate did not show statistically significant differences (χ2 =0. 781, P >0. 05). Multivariate analysis showed that pathological grading and tumor size are the risk factors of prognosis of gliomas, postoperative radiotherapy and chemotherapy are the protective factors for prognosis (RR=1. 094, RR=1. 387, RR=0. 513, P <0. 05). Conclusion Surgical microscope in improving cerebral glioma patients cognition, life ability and level of the neuropeptide as-pects have a significant advantage;pathological grading and tumor size are risk factors for prognosis of glioma, postoperative radiotherapy and chemotherapy are the protective factor for prognosis.关键词
脑胶质瘤/显微镜手术/大骨瓣开颅术/神经肽/瘤坏死因子-α/预后Key words
Brain glioma/Microsurgical operation/Standard large trauma craniotomy/Neuropeptide/Tumor necrosis factor alpha/Prognosis
