摘要
Abstract
Objective To investigate the correlation between male sex hormones and blood lipid metabolism in middle age and elderly men. Methods From 2013 January to 2014 December, to collect routine examination men aged 40 and over 644 cases, aged 40-82 years old. Determination of the serum levels of sex hormones, follicle stimulating hormone ( FSH) , lu-teinizing hormone ( LH) and estradiol ( E2 ) , total testosterone ( TT) , sex hormone binding globulin ( SHBG) , free testoster-one (FT), and lipid levels, including high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol ( LDL-C) , total cholesterol ( TC) and triglycerine ( TG) . And the correlation between the indexes of sex hormones and the in-dexes of blood lipids was analyzed. Results Along with the increase of age, FSH, LH and SHBG increased gradually ( P <0. 01), FT decreased gradually ( P <0. 01). The age group of 51-60, 61-70, TT and HDL-C was significantly higher than 40-50 years group and > 70 years group ( P <0. 01). The level of TG decreases with the increase of age ( P <0. 01). Correlation analysis showed that serum hormone and lipid levels in the present universal relevance, after adjustment for age and body mass index (BMI), FSH and SHBG and HDL-C still showed significant positive correlation ( r =0. 08, r =0. 18, P < 0. 01 or P <0. 05), LH and SHBG and TC is still showing a significantly negative correlation ( r = -0. 08, r =-0. 08, P < 0. 01). TT, SHBG and TG still showed a significant negative correlation ( r = -0. 16, r = -0. 20, P <0. 05). Multiple linear regression analysis showed that, FSH and SHBG and HDL-C were significantly positive correlation (β= 0. 010, P = 0. 001;β=0. 004, P =0. 02), luteinizing hormone (LH) and HDL-C significantly negative correlated (β=-0. 020, P =0. 001), TT and TG significantly negative correlated (β= -0. 080, P =0. 01). Conclusion In middle-aged and elderly men, low concentrations of FSH and SHBG, and high concentrations of LH have risk of increased dyslipidemia ( low HDL-C) , and low TT also increase the risk of dyslipidemia ( high TG) .关键词
性激素/脂质/相关性/男性/中老年Key words
Sex hormone/Lipid/Correlation/Male/Elderly
