疑难病杂志Issue(8)：828-831,834,5.DOI:10.3969/j.issn.1671-6450.2015.08.017
学龄期哮喘儿童呼出气一氧化氮变化与肺功能及外周血嗜酸性粒细胞的相关性分析
The analysis of fractional exhaled nitric oxide in children with asthma and the correlation with lung function and pe-ripheral eosinophil percentage
摘要
Abstract
Objective To investigate the correlation of school-age children with asthma in different periods call outlet changes of fractional exhaled nitric oxide (FeNO), as well the pulmonary function and peripheral blood eosinophils eosino-phil. Methods Seventy-one cases of school age children with bronchial asthma were enrolled, 41 patients with acute episode as an acute attack period subgroup, 30 cases of chronic phase as chronic persistent subgroups, 26 cases of age matched healthy children as healthy control group. All enrolled children’ s FeNO concentration, routine pulmonary ventilation function and pe-ripheral blood eosinophil eosinophil were detected. Three groups of children’ s FeNO differences were compared, and the re-ceiver operating characteristic ( ROC) analysis were used to determine the optimal cutoff value of asthma; study of FeNO in asthmatic children and the maximum peak expiratory flow rate measured value was expected to account for a percentage of the value ( PEF% pred) , 75% forced expiratory flow rate measured value is expected to account for a percentage of the value of FEF75%pred, these indexes and peripheral blood eosinophils eosinophil percentage (EOS%) were analyzed. Results (1) Acute attack subgroup, chronic persistent period subgroup’s sensitivity was 0. 78, specificity was 0. 96. FeNO concentration in children patients were higher than those of healthy control group ( P <0. 05), acute attack subgroup’s FeNO concentration was higher than that of chronic persistent subgroups ( P <0. 05). The area under the ROC curve showed that the best value of FeNO for diagnosis of asthma was 26. 6ppb. (2) In patients with asthma acute attack period subgroup, lung function index PEF%pred, FEF75%pred were decreased, and FEF75%pred decreased more significantly; chronic duration subgroup com-pared with acute attack subgroup, index of pulmonary function were improved. Acute attack chronic subgroup, chronic persis-tent subgroup’s EOS% were higher than those in control group ( P <0. 05). (3) Asthma in different periods’ FeNO had no significant correlation (acute attack period subgroup:r = -0. 072, P =0. 653, r = -0. 194, P =0. 224;chronic period sub-group:r = -0. 193, P =0. 306, r =0. 253, P =0. 177);acute exacerbation and FeNO had weak correlation ( r =0. 389, P =0. 012), chronic persistent subgroup and healthy control group’ s FeNO EOS% had no significant correlation ( r =-0. 086, P =0. 653, r =0. 169, P =0. 409). Conclusion The FeNO can assist diagnosis of school-age children with asth-ma, as acute exacerbation of asthma risk or poor control performance index, but there are certain limitations. There was no significant correlation between FeNO and lung function, in the acute phase, had weak correlation with EOS%.关键词
支气管哮喘/呼出气一氧化氮/肺功能/嗜酸性粒细胞/儿童/学龄期Key words
Bronchial asthma/Fractional exhaled nitric/Pulmonary function/Eosinophil eosinophil/Children/School-age引用本文复制引用
李金英,李权恒,安淑华,王翠芝,孙军锋..学龄期哮喘儿童呼出气一氧化氮变化与肺功能及外周血嗜酸性粒细胞的相关性分析[J].疑难病杂志,2015,(8):828-831,834,5.基金项目
河北省科学技术支撑计划项目(No.112761132) （No.112761132）
