云南师范大学学报（自然科学版）Issue(6)：62-68,7.
丹参素及其衍生物合成方法的研究进展∗
Advances of Synthesizing Danshensu and Its Derivatives
摘要
Abstract
Danshensu,the active component of Danshen,is a kind of organic compound with simple but particular chemical structure,and widespread physiological and pharmacological activities,es-pecially in the anti-myocardial ischemia and liver protection.However,the sources of Danshensu (or its derivatives)which are isolated from Danshen are limited and could not satisfied the clini-cal need.Therefore,how to synthesis Danshensu(or its derivatives)simply and effectively using chemical methods is the crucial problem needing to be solved during the process of drug develop-ment.In the essay,the relative reports in recent years were reviewed and the synthesis pathway for racemic body and optic pure danshensu were discussed,the structure-function relationship were primarily analyzed,among them,how to synthesis optic pure danshensu using simply,high effective and selective method remain to be the focus of medical chemistry and organic chemis-try.The study regarding novel synthesis methods and detailed exploration of structure-function relationship would provide basis for the development of Danshensu-like drugs.关键词
丹参素/药物合成/不对称催化/构效关系Key words
Danshensu/Drug synthesis/Asymmetrical catalysis/SAR分类
化学化工引用本文复制引用
李俊鹏,杨涵,陈家林,周利民,崔浩,陈立桥..丹参素及其衍生物合成方法的研究进展∗[J].云南师范大学学报（自然科学版）,2014,(6):62-68,7.基金项目
国家自然科学基金资助项目(51261008) （51261008）
云南锡业集团科技计划资助项目(2013010504) （2013010504）
