烟台大学学报（自然科学与工程版）Issue(3)：197-200,223,5.
盐酸安舒法辛对嗅球摘除大鼠抑郁行为及血清皮质酮、睾酮的影响
Effect of Ansofaxine Hydrochloride on Depression Behavior, Serum Corticosterone Ketone and Testosterone Levels in Olfactory Bulbectomized Rats
摘要
Abstract
The effects of Ansofaxine Hydrochloride on behavior, serum corticosterone ketone and testosterone levels in depressed model rats are investigated after olfactory bulb removal. The olfactory bulbectomized rats are randomly divided into six groups and are intragastrically administered Ansofaxine Hydrochloride for 20 days continuously. Lo-comotor activity and sucrose consumption are measured. Serum levels of corticosterone and testosterone are analyzed using ELISA. The results show that Ansofaxine Hydrochloride can significantly reduce the numbers of standings and crossings , and increase the rate of sugar consumption in model rats after olfactory bulb removal. Moreover, the drug treatment increases the testosterone level and decreases the corticosterone level in serum of depressed model rats. These results indicate that Ansofaxine Hydrochloride can significantly reverse the behavioral changes in olfac-tory bulbectomized rats. This might be due to its modulating effect on HPA axis.关键词
盐酸安舒法辛/嗅球摘除/皮质酮/睾酮Key words
Ansofaxine Hydrochloride/olfactorybulbectomized/corticosterone/testosterone分类
医药卫生引用本文复制引用
何杰,林菲,董秋菊,邢艳丽,田京伟..盐酸安舒法辛对嗅球摘除大鼠抑郁行为及血清皮质酮、睾酮的影响[J].烟台大学学报（自然科学与工程版）,2014,(3):197-200,223,5.基金项目
国家科技部十一五重大新药创制(2011ZX11102) （2011ZX11102）
