烟台大学学报（自然科学与工程版）Issue(1)：70-74,5.DOI:10.13951/j.cnki.371213/n.2015.01.015
棒棒木不同提取部位初步药效学研究
Preliminary Studies on Pharmacological Effects of Different Extracts from Celtis bungeana Bl
摘要
Abstract
The antitussive effects of different extracts from Celtis bungeana Bl are studied in mice using ammonia in-duced cough model. The analgesic and anti-inflammatory effects of these extracts are studied using dimethyl-benzene-induced auricle swelling model, acetic acid induced mouse writhing model and hot-plate experiment. The results show that Celtis bungeana Bl extract fractions of petroleum ether and n-butanol can obviously prolong the la-tent period and reduce the times of mouse coughing induced by aqueous ammonia. But ethyl acetate extract has no significant effect on the latency period of cough and cough frequency compared with the control group. Among vari-ous extracts, the n-butanol extract is the best, which can relieve mouse aurical swelling caused by xylene and can reduce the writhing frequency in the hot plate experiment of mice. Petroleum ether and n-butanol extract fractions can significantly improve the pain threshold in hot-plate experiment. The ethyl acetate extract shows no significant effect compared with the control group. It is concluded that various Celtis bungeana Bl extracts have anti-inflamma-tory effect and analgesic effect on peripheral pain, the main effective fractions are petroleum ether and n-butanol ex-tracts, which show favorable antitussive effect and analgesic effect on central pain.关键词
棒棒木/提取物/镇咳作用/抗炎作用/镇痛作用Key words
Celtis bungeana Bl/extract/antitussive effect/anti-inflammatory effect/analgesic effect分类
医药卫生引用本文复制引用
于晨,李洪娟,李秀秀,王建玉,葛蒙蒙..棒棒木不同提取部位初步药效学研究[J].烟台大学学报（自然科学与工程版）,2015,(1):70-74,5.基金项目
烟台市科学技术发展计划项目(2013WS262) （2013WS262）
山东省自然科学基金资助项目(ZR2010HL065) （ZR2010HL065）
