摘要
Abstract
As the population ages, Parkinson's disease (PD) has become a disease severely af ecting the quality of the patients' life, especial y for those with advanced PD whose ef icacy of dopaminergic drugs decreases, while the side ef ects also increases. Deep Brain Stimulation (DBS) is an alternative way of treatment which developed in recent years. It can improve both the motor symptoms(MS) and the non-motor symptoms(NMS), thus improving the quality of life. The current widely used DBS targets are subthalamic nuclei (STN) and the globus pal idus interna (GPi). However, the STN-DBS seems to be more widely used, and this fact may be at ributed to the obvious reduction of the daily levadopa equivalent dose (LED) induced by STN-DBS. Many recent international clinical trials support that the STN DBS and GPi - DBS has no obvious dif erence in motor symptoms, but they dif er in several mild dif erences in non-motor symptoms, which may indicate some potential advantages of GPi - DBS. Meanwhile, with the dif erences between the STN and GPi clearing, the inclusive and exclusive criteria for the patients who tend to have DBS should be strictly ruled, the dif erences between patients should be individualized, then the individual therapy could be realized which would benefit the patients with advanced PD further. Therefore, the inclusive and exclusive criteria for PD patients is also an important part of DBS. Combined with the latest researchs in the field of DBS for PD, this clinical review focuses on the aspects above.关键词
脑深部电刺激术/帕金森病/丘脑底核/苍白球Key words
Deep brain stimulation/Parkinson disease/Subthalamic nucleus/Globus pal idus
