摘要
Abstract
Objective To explore the prognostic factors of malignant biliary obstruction patients after percutaneous transhepatic cholangial drainage (PTCD)or biliary metal stent implantation. Methods The clinical and pathological and 1 years of fol ow-up data for 102 patients with malignant biliary obstruction who underwent PTCD or biliary metal stent implantation were retrospectively col ected. The prognostic factors of malignant biliary obstruction patients after interventional therapy were analyzed by Cox proportional hazards regression model. Results 1.The median survival time was 6.89 ±2.58 months, and the 6mo and 12mo cumulative survival rates were 54.14% and 27.81%. 2. Univariate analysis showed that complication, obstruct, tumor size, tumor stage and the total number of white blood cells were the main prognosis factors in these patients ( <0.05). However, gender, age, total bilirubin, aspartate aminotransferase, alanine aminotransferasem, Alkaline phosphatase, gamma glutamyl transpeptidase and hemoglobin content were not significant predictors of the prognosis in these patients ( >0.05). 3. Multivariate analysis showed that complication (RR=1.874), obstruct (RR=2.140), tumor size (RR=1.051), the total number of white blood cells (RR=1.023) and tumor stage (RR=2.296) were independent prognostic factors in these patients. Conclusion Complication, obstruct, tumor size, the total number of white blood cells and tumor stage are independent risk factors, and can be helpful for prognosis of malignant biliary obstruction patients who received interventional therapy.关键词
恶性梗阻性黄疸/金属支架/生存分析/预后Key words
Malignant biliary obstruction/Metal stent/Survival analysis
