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吡唑并[1,5-a]嘧啶酮类M通道开放剂脂水分配系数的测定及计算

李瑞宏沈立茹祁金龙

医学信息Issue(15)：225-226,2.

吡唑并[1,5-a]嘧啶酮类M通道开放剂脂水分配系数的测定及计算

Detection and Calculation for Lipohilicity (Log P) of PPOs compound M Channel Openers

李瑞宏 ¹沈立茹 ²祁金龙³

作者信息

1. 河北省儿童医院药剂科，石家庄河北 050031
2. 唐山市食品药品检验中心，唐山河北 063000
3. 河北医科大学药理教研室，石家庄河北 050071
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摘要

Abstract

Objective To calculate and detect the lipohilicity ( Log P ) of PPOs compound, including QO-58, QO-58-L, QO-58-Cl as M channel openers, and to compare the conformity of two results.Methods Determined by high performance liquid chromatography, the peak area of QO-58, QO-58-L and QO-58-Cl can infer their lipid-water partition coef icient ( octanol / water ). The fixed phase is Spherisorb C18 ( 34/118 ) 10L 4.6 í 250 mm reverse column, and the mobile phases are acetonitrile-0.2mol/L ammonium acetate ( 57:43, QO-58 ), acetonitrile-0.2mol/L ammonium acetate ( 57:43, QO-58-L ), methanol-0.2mol/L ammonium acetate ( 85:15, QO-58-Cl ). Results QO-58 log P=2.43, QO-58-L log P=1.07, QO-58-Cl log P=5.50.Conclusion After structural modification, the lipid-water partition coef icient of PPOs wil change. Software verifies its trend correct.

关键词

高效液相色谱法/QO-58/QO-58-L/QO-58-Cl/脂水分配系数

Key words

HPLC/QO-58/QO-58-L/QO-58-Cl/log P

引用本文复制引用

李瑞宏,沈立茹,祁金龙..吡唑并[1,5-a]嘧啶酮类M通道开放剂脂水分配系数的测定及计算[J].医学信息,2014,(15):225-226,2.

医学信息

ISSN：1006-1959

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