医学信息Issue(16)：657-659,3.
基于转铁蛋白受体（TfR1）的肿瘤与脑部疾病靶向治疗研究进展
Based on the Transferrin Receptor (TfR1) of the Tumor and Brain Disease Progress in Targeted Therapy
邵明 1刘煜1
作者信息
- 1. 中国药科大学生命科学与技术学院，江苏 南京 210009
- 折叠
摘要
Abstract
Human TfR1 was universal y expressed in dif erent tissues. The major function of TfR1 was to facilitate delivery of transferrin across cells and blood-brain barrier (BBB). As a result, iron homo-stasis was maintained. TfR1 was recognised as a critical target for tumor and brain disease therapy due to its over expression in tumor cells and BBB. In recent years, drug carriers based on TfR1 recognition were developed such as Transferrin (Tf), anti-TfR1 antibody and TfR1 binding peptide. These carriers bind to TfR1 specifical y and enter into cellor BBB through receptor mediated endocytosis. Chemicals conjugated with these carriers can be facilitated to enter into tumor cells and brain tissue. Therapeutic proteins can be engineered to fused with anti-TfR1 antibody and transported across BBB.关键词
转铁蛋白受体/肿瘤靶向治疗/脑靶向给药Key words
TfR1/Tumor target therapy/Brain directed delivery引用本文复制引用
邵明,刘煜..基于转铁蛋白受体（TfR1）的肿瘤与脑部疾病靶向治疗研究进展[J].医学信息,2014,(16):657-659,3.
