医学信息Issue(19)：194-195,2.
泮托拉唑对耐亚胺培南的鲍曼不动杆菌主动外排泵的抑制作用
Inhibition Effect of Pantoprazole on Active Efflux Pump in Baumannii Acinetobacter in Imipenem Resistant Strains
摘要
Abstract
Objective To understand the role and distribution of multidrug ef lux pumps in clinical isolates of carbapenems resistant Acinetobacter baumannii, investigate the reversal resistant in Acinetobacter baumanni by pantoprazole, and thus to provide information for selection of antibiotics for the treatment of mutlidrug-resistant infections. Methods A total of 36 non-duplicate clinical isolates were recovered and antimicrobial susceptibility was conducted by agar dilution methods with or without the inclusion of pantoprazole or carbonyl cyanide-m-chlorophenylhydrazone (CCCP) . Results The results showed that 13 isolates after treatment of imipenem with CCCP were positive of ef lux mechanism(their MIC reduced by 4 times or more). The same result was deteced when pantoprazole and imipenem were added to the dilution ( <0.05). Conclusion Ef lux plays a important role in carbapenems resistance in the clinical isolates of A.baumanni . Pantoprazole could enhance antibiotic acticities of imipenem to Acinetobacter baumanni including multidrug ef lux pumps,and has certain application prospect.关键词
鲍曼不动杆菌/外排泵抑制剂/亚胺培南Key words
Bauman Acinetobacter/Ef lux pump inhibitors/Imipenem分类
医药卫生引用本文复制引用
周秩权,周建伟,夏忠弟..泮托拉唑对耐亚胺培南的鲍曼不动杆菌主动外排泵的抑制作用[J].医学信息,2014,(19):194-195,2.基金项目
湖南省卫生厅科研基金项目号B2013-051 （）
