医学信息Issue(19)：230-231,2.
头孢曲松在家兔胆汁中的药物浓度分布的研究
Study on the Drug Concentration in Rabbit Bile of Ceftriaxone
郑惊雷 1梁力建 2王在国 1陈刘镇 1胡夏荣 1何润沛 1叶振伟1
作者信息
- 1. 广东省东莞市人民医院肿瘤外科，广东 东莞 523059
- 2. 中山大学附属第一医院肝胆外科，广东 广州 510080
- 折叠
摘要
Abstract
Objective To study the distribution of ceftriaxone in rabbit bile. Methods The rabbits were administered i.v. with ceftriaxone and their drug concentrations in bile were measured by HPLC. Parameters of ceftriaxone were analyzed by Shanghai Hongneng pharmacokinetic sofeware, such as maximum concentration(Cmax),peak time (Tmax),half-life time(T1/2),clearance(CL) and apparent volume of distribution(VD). Results After a single i.v. administration of 75mg/kg of ceftriaxone, Cmax(1509.20±584.60)μg/ml was reached at Tmax (0.036±0.094)h in bile. After 8h of the injection ,the concentration of ceftriaxone remained much higher than the MIC90 of most biliary pathogens. Conclusion Ceftriaxone reaches high concentration in bile, which indicates that it is a practical and promising antibiotic for the treatment of biliary tract infection.关键词
头孢曲松/胆汁/浓度/分布/高效液相色谱法Key words
Ceftriaxone/Bile/Concentration/Distribution/HPLC引用本文复制引用
郑惊雷,梁力建,王在国,陈刘镇,胡夏荣,何润沛,叶振伟..头孢曲松在家兔胆汁中的药物浓度分布的研究[J].医学信息,2014,(19):230-231,2.
