摘要
Abstract
Objective Using RT-PCR technique in the nucleic acid level to detected the gene expression of TFF3, C1orf24 in thyroid tumor tissues,that was extracted from patients by fine-needle aspiration biopsy.To assess whether it can be used clinical y in the identification of benign and malignant thyroid fol icular type tumor. Methods 279 cases of fine-needle aspiration tissue samples were col ected from patients with thyroid nodules between April 2013 and April 2011 in Jinling hospital.Then using RT-PCR technique in nucleic acid level to detected TFF3, C1orf24 gene expression level in each tissue sample.Contrast the cytology and postoperative pathology examination results,To learn the gene expression level of TFF3 and C1orf24 whether there are dif erences between thyroid fol icular tumor and malignant thyroid fol icular tumor. Results The gene expression level of TFF3 was higher in Fol icular thyroid carcinoma group compared to Thyroid fol icular adenoma group ( <0.05). Conclusion Two kinds of molecular biomarkers can help clinical identification of thyroid fol icular type of benign and malignant tumors.关键词
细针穿刺活检(FNAB)/甲状腺结节/甲状腺滤泡状腺瘤/甲状腺滤泡状癌/生物标记物/TFF3/C1orf24/RT-PCRKey words
Fine needle aspiration biopsy (FNAB)/thyroid nodule/thyroid fol icular adenoma/thyroid cancer/biomarker/TFF3/C1orf24/RT-PCR
