医学信息Issue(22)：74-75,2.
血栓性血小板减少性紫癜12例临床分析
Thrombotic Thrombocytopenic Purpura:Clinical Analysis of 12 Cases
刘景华 1周凡 1刘彦琴 1王吉刚 1白颖 1刘洋 1惠玉 1张晓琳 1李敏燕1
作者信息
- 1. 沈阳军区总医院血液内科，辽宁 沈阳 110016
- 折叠
摘要
Abstract
Objective To investigate clinical features,outcome and laboratory characteristics of thrombotic thrombocytopenic purpura (TTP) and improve diagnostic ability for physician in TTP management. Methods Totally 12 diagnosed TTP from 2008.1 to 2013.12 were analyzed clinical features, laboratory characteristics and treatment. Results ①There were 8 patients with the pentad of TTP,including hemolytic anemia, thrombocytopenia, neurologic abnormalities, fever and kidney injury. 11 patients had triad of TTP. ②Al the patients had high level of lactate dehydrogenase, and the schistocytes of peripheral blood smears were present in al cases with a arrange of 2%~15%. The primary disease: 1 cases of lymphoma, antiphospholipid antibody syndrome and 1 cases of LPS, 1 cases of systemic lupus erythematosus SLE, immune factors in 5 cases, infection in 2 cases, 2 cases with unknown causes.④The treatment with plasmapheresis, plasma infusion, rituximab, glucocorticoid, the ef ective rate of treatment 82.7%.Conclusion The early of diagnosis of TTP is stil based on clinical feature, dif erential diagnosis should be completed at the time that of preemption of treatment with plasma exchange and rituximab.关键词
血栓性血小板减少性紫癜/血浆置换/利妥昔单抗Key words
Thrombotic thrombocytopenic purpura/Plasma exchange/Rituximab分类
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刘景华,周凡,刘彦琴,王吉刚,白颖,刘洋,惠玉,张晓琳,李敏燕..血栓性血小板减少性紫癜12例临床分析[J].医学信息,2014,(22):74-75,2.
