摘要
Abstract
Objective To observe the influence and the correlation of HBV-DNA levels, liver function, HBsAg levels and peripheral blood T lymphocyte subsets with the therapy of adefovir ester and bicyclol in HBeAg negative expression of CHB patients before and after the treatment. Methods 87 cases of HBeAg negative CHB, randomly divided into adefovir ester group (control group) and joint bicyclol adefovir ester group (observation group), patients in control group take adefovir ester, and observing group take bicyclol and adefovir ester, period of treatment, a total of 48 weeks. Respectively, at 12, 24 and 48 weeks follow-up and detection of liver function and HBV DNA levels, HBsAg level, the change of peripheral blood T lymphocyte subsets and evaluate the relationship between each other. Results Compared with before treatment, the fol ow-up points of two groups of liver function were improved, in weeks 12 the liver function recovery is bet er than the control group; Compared with before treatment, the fol ow-up points HBV-DNA and HBsAg of two groups were improved, and in weeks 12, 24 ,the HBV-DNA and HBsAg index in the observation group is better than the control group; Compared with before treatment, the dif erence of lymphocyte subgroup of CD8 +, CD4 + / CD8 + in two groups of 24 and 48 weeks were statistical y significant, and in 24 weeks CD8 +, CD4 + / CD8 + were statistically significant dif erence between the two groups; Before and after treatment the serum HBV-DNA load and AST, ALT levels are positive correlation; The serum HBV-DNA level have positive correlation with CD8 +, and have negative correlation with CD4+/CD8+. The serum HBV-DNA levels and HBsAg have quantitative positive correlation. Conclusion Taking Adefovir ester with bicyclol tablet in the treatment of HBeAg negative CHB can improve clinical symptoms faster than take adefovir ester alone, dynamic HBV-DNA quantitative monitoring can be used for ef ective monitoring the CHB efficacy of HBeAg negative markers.关键词
阿德福韦酯/双环醇/HBeAg阴性/乙型肝炎病毒Key words
Adefovir ester/Bicyclol/HBeAg negative/Hepatitis B virus
