周红林 1姜祖光 1岳文彬 1刘月芬 1李慎柯 1陈青1
作者信息
- 1. 濮阳市油田总医院肿瘤科，河南 濮阳 457000
- 折叠
摘要
Abstract
Objective To compare and analyze the ef icacy and safety of docetaxel -containing regimen for patients with advanced gastric cancer. Methods Col ect 119 patients with advanced gastric cancer treated by chemotherapy in General surgery and Oncology from march 2011 to December 2013,al these case were treated with docetaxel-containing regimen first time, 47 patients with DCF regimen(DTX75mg/㎡,iv,d1,DDP20mg/㎡,iv,d1~d3,5-FU400 mg/㎡iv,d1~d5,LV300mg,iv,d1~d5,q3w),72patients with DC regimen(DTX75mg/㎡,iv,d1,DDP20mg/㎡,iv,d1~d3).The ef icacy and the toxicity were evaluated after two cycles. Results Al the cases could be evaluated ef icacy and toxicity, There was no statistical significance about the recent Response rate(RR) and the disease control rate (DCR) between the two groups, Toxicity of two groups were tolerable ,For the 3~4 degree toxicity, There was no statistical significance about neurotoxin and muscular pain. While the incidence rate of leucopenia, Nausea, vomit, weak, Diar hea were lower in DC regimen group than in DCF regimen group with significance dif erence. Conclusion The treatment of patients with advanced gastric cancer, DC regimen group and DCF regimen group had the similar ef ect, but the doublet regimen group had bet er tolerance, lower toxicity.关键词
胃癌/多西他赛/化学治疗/毒副作用Key words
Gastric cancer/Docetaxel/Chemotherapy/Toxicity
