医学信息Issue(14)：18-18,1.
破血化瘀、填精补髓法对实验性脑出血大鼠血肿周围脑组织GSK-3β信号通路的作用研究
Effect of Decoction of Poxue Huayu and Tianjing Busui on the Expression of GSK-3βto the Perihematomal Tissue in Experimental ICH Rats
摘要
Abstract
Object ive To investigate the ef ect of decoction of Poxue and Tianjing on the expression of brain derived neurotrophic factor GSK-3βand its receptor to the perihematomal tissue in experimental ICH Rats.Methods Using WISTAR rats as the model rats of cerebral hemor hage.It is designed to observe the ef ect of the behavioristic index that how the Decoction of Poxue and Tianjing could improve the neurological deficit of the rats.There is also a experiment which is designed to observe the protein expression of GSK-3β.Results Compared with the model control group,the positive drug group and the investigational drug groups rats'neurological signs are improved after 1 and 3 days'administration.At the third,the seventh and fourteenth day of administration,compared with the model group,high and medium-dose group damaged brain area GSK-3βquantity are clearly increased ( <0.05 or <0.01, <0.05). Conclusion The experiment has proved that the intracerebral hemorrhage rats'neurological deficit has been evidently improved by the Poxue and Tianjing prescription.And it has been proved from the molecular level that the mechanism might be increasing the expression of GSK-3βto the perihematomal tissue in experimental ICH rats.关键词
脑出血/GSK-3β/破血化瘀/填精补髓Key words
Intracerebral hemor hage/GSK-3β/Poxue and Tianjing引用本文复制引用
程远,赵建军..破血化瘀、填精补髓法对实验性脑出血大鼠血肿周围脑组织GSK-3β信号通路的作用研究[J].医学信息,2015,(14):18-18,1.基金项目
吉林省卫生厅卫生科研计划项目(课题编号2013Z046)。 （课题编号2013Z046）
