医学信息Issue(21)：40-41,2.
脱管散对金黄色葡萄球菌生物膜作用的初步研究
Preliminary Study on the Effects of Tuoguansan in Staphylococcus Aureus Biofilms Biofilm
陈多平 1李春梅 2张晓刚 3曹林忠 4张秀4
作者信息
- 1. 甘肃中医学院，甘肃 兰州 730000
- 2. 甘肃张掖市人民医院，甘肃 张掖 734000
- 3. 甘肃张掖市人民医院，甘肃 张掖 734000
- 4. 甘肃省中医学院附属医院，甘肃 兰州 730000
- 折叠
摘要
Abstract
Objective To investigate the ef ect of TuoGuansan Staphylococcus aureus biofilms.Methods Through brown plate improved method,to cultivate Staphylococcus aureus biofilms in vitro, according to tube dilution method TuoGuanSan minimum inhibitory concentration (MIC)were measured,respectively TuoGuansan diluted to 1/4,1/2,1.5-fold,2-fold.To observe the changes of the drug at dif erent concentrations and dif erent time by electron microscopy.Results Within 7 days of staphylococcus aureus biofilm formation stability When the concentration of TuoGuansan to 30 mg/ml(1/4), 60 mg/ml(1/2)concentrations.there was no dif erence in bacterial biofilms at each time point and the control group,there was no dif erence between groups at dif erent time.180 mg/ml(1.5 times),240 mg/ml(2 times),360 mg/ml(three times)of staphylococcus aureus have obvious scavenging ef ect on BF,and with the car ier concentration increases gradual y reduced the number of bacteria;under 360 mg/ml concentration ef ect aureus was completely cleared within 24h.Conclusion It has clinical development use value because of TuoGuansan'sAntimicrobial properties.关键词
金黄色葡萄球菌/生物膜/脱管散Key words
Staphylococcus aureus/Biofilm/TuoGuansan引用本文复制引用
陈多平,李春梅,张晓刚,曹林忠,张秀..脱管散对金黄色葡萄球菌生物膜作用的初步研究[J].医学信息,2015,(21):40-41,2.
