摘要
Abstract
Objective To investigate the significance of serum thymidine kinase 1 (thymidine kinase 1,TK1)detection in patients with non-smal cel lung cancer who received radical surgery.Methods The serum TK1 levels have been detected by Western blot-enhanced chemiluminescence assay.44 patients received serum TK1 detection before radical surgery and were fol owedup for 6~18 months,of witch 20 patients received after operation to analyze the cor elations between recur ence and serum TK1 level.Results Postoperative relapse-free survival rate in patients with preoperative high serum TK1 level (>0.94pM)was significantly lower than the patients with preoperative low serum TK1 level (≤0.94pM)( <0.05).Combined with preoperative TNM staging,tumor dif erentiation degree and the level of TK1,the sensitivity of prediction of recur ence and metastasis after operation can be significantly improved (95%).The serum TK1 levels decreased one month after operation ( <0.05).After operation,the levels of serum TK1 in patients with recurrence and metastasis were higher than the others ( <0.05).Conclusion The serum thymidine kinase 1 detection has a certain value in prediction and diagnosis of recur ence and metastasis.关键词
血清胸苷激酶1(TK1)/非小细胞肺癌/根治术/复发转移Key words
Serumthymidine kinase 1/Non-smal cel lung cancer/Radical surgery/recur ence and metastasis
